Synchronous Pulmonary Adenofibroma and Solitary Fibrous Tumor: Case Report and Review of the Literature

Pulmonary adenofibroma (PAF) is a rare neoplasm that may be related to solitary fibrous tumor (SFT). A subset of PAFs harbor the NAB2-STAT6 fusion that is typical of SFT, but a significant proportion do not. Their distinction is clinically important as SFTs can potentially have an aggressive clinica...

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Bibliographic Details
Published in:International journal of surgical pathology 2019-05, Vol.27 (3), p.322-327
Main Authors: Olson, Nicholas J., Czum, Julianna M., de Abreu, Francine B., Linos, Konstantinos, Black, Candice C.
Format: Article
Language:English
Subjects:
Case reports
Lung cancer
Tumors
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Summary:Pulmonary adenofibroma (PAF) is a rare neoplasm that may be related to solitary fibrous tumor (SFT). A subset of PAFs harbor the NAB2-STAT6 fusion that is typical of SFT, but a significant proportion do not. Their distinction is clinically important as SFTs can potentially have an aggressive clinical course, while there has been no report of a PAF behaving in a malignant fashion. We report a case of a 60-year-old male who developed a SFT and PAF in the same lung. The SFT harbored a NAB2-STAT6 fusion, while the PAF did not have any identifiable fusion. This case represents the first instance of a single patient with both of these tumors occurring simultaneously in the same lung.
ISSN:1066-8969
1940-2465
DOI:10.1177/1066896918807302