Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii

Three new bisindole alkaloids, bisleuconothines B–D (1–3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2018-11, Vol.81 (11), p.2600-2604
Main Authors: Nugroho, Alfarius Eko, Zhang, Wenjia, Hirasawa, Yusuke, Tang, Yiming, Wong, Chin Piow, Kaneda, Toshio, Hadi, A. Hamid A, Morita, Hiroshi
Format: Article
Language:English
Subjects:
A549 Cells
Aspidosperma - chemistry
Humans
Indole Alkaloids - chemistry
Indole Alkaloids - isolation & purification
Molecular Structure
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Summary:Three new bisindole alkaloids, bisleuconothines B–D (1–3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16–C-10′ and C-2–O–C-9′. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/acs.jnatprod.8b00749