Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp

Curvulaide A ( 1 ), a new bicyclic polyketide, together with its known congener preussilide D, were produced by solid-state fermentation with Curvularia sp. IFB-Z10. The structure of 1 was elucidated using a combination of spectral methods, including extensive one-dimensional (1D) and two-dimensiona...

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Bibliographic Details
Published in:Journal of antibiotics 2019-02, Vol.72 (2), p.111-113
Main Authors: Liu, Wei-He, Ding, Yi, Ji, Xiang, An, Fa-Liang, Lu, Yan-Hua
Format: Article
Language:English
Subjects:
101/58
101/6
631/154/309/2144
692/308/153
96/2
Anaerobic bacteria
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Brief Communication
Cytotoxicity
Fermentation
Ionization
Ions
Life Sciences
Mass spectrometry
Medicinal Chemistry
Microbiology
NMR
Nuclear magnetic resonance
Organic Chemistry
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Summary:Curvulaide A ( 1 ), a new bicyclic polyketide, together with its known congener preussilide D, were produced by solid-state fermentation with Curvularia sp. IFB-Z10. The structure of 1 was elucidated using a combination of spectral methods, including extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) data, high resolution electrospray ionization mass spectrometry (HRESIMS), experimental and calculated electronic circular dichroism (ECD) spectra. Curvulaide A ( 1 ) exhibited moderate anti-anaerobic bacteria activity against periodontal pathogen Porphyromonas gingivalis with the MIC value of 62.5 μM, and showed moderate cytotoxicity against human hepatoma cell lines BEL7402/5-Fu with IC 50 values of 12.46 μM.
ISSN:0021-8820
1881-1469
DOI:10.1038/s41429-018-0110-7