Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non‐alcoholic fatty liver disease

Aim The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis‐4 (FIB‐4) index in a large general population cohort that underwent a health checkup. Methods A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intak...

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Bibliographic Details
Published in:Hepatology research 2019-03, Vol.49 (3), p.296-303
Main Authors: Tanaka, Kenichi, Takahashi, Hirokazu, Hyogo, Hideyuki, Ono, Masafumi, Oza, Noriko, Kitajima, Yoichiro, Kawanaka, Miwa, Chayama, Kazuaki, Saibara, Toshiji, Anzai, Keizo, Eguchi, Yuichiro
Format: Article
Language:English
Subjects:
Alcoholic beverages
Bile
Blood glucose
Epidemiology
Fatty liver
Fibrosis
FIB‐4 index
health checkup
Hemoglobin
hemoglobin A1c
Hepatitis B
Liver diseases
Multivariate analysis
non‐alcoholic fatty liver disease
ultrasonography
Ultrasound
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Summary:Aim The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis‐4 (FIB‐4) index in a large general population cohort that underwent a health checkup. Methods A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intake were enrolled. Non‐alcoholic fatty liver disease (NAFLD) was diagnosed by ultrasonography and potential liver fibrosis (FIB‐4 index ≥1.3) in NAFLD was analyzed in relation to HbA1c level. Factors associated with potential liver fibrosis of NAFLD were also analyzed. Results The overall frequency of NAFLD was 27.9% (1935 subjects) and the frequency of NAFLD by HbA1c level (
ISSN:1386-6346
1872-034X
DOI:10.1111/hepr.13282