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Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non‐alcoholic fatty liver disease
Aim The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis‐4 (FIB‐4) index in a large general population cohort that underwent a health checkup. Methods A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intak...
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| Published in: | Hepatology research 2019-03, Vol.49 (3), p.296-303 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 303 |
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| container_start_page | 296 |
| container_title | Hepatology research |
| container_volume | 49 |
| creator | Tanaka, Kenichi Takahashi, Hirokazu Hyogo, Hideyuki Ono, Masafumi Oza, Noriko Kitajima, Yoichiro Kawanaka, Miwa Chayama, Kazuaki Saibara, Toshiji Anzai, Keizo Eguchi, Yuichiro |
| description | Aim
The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis‐4 (FIB‐4) index in a large general population cohort that underwent a health checkup.
Methods
A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intake were enrolled. Non‐alcoholic fatty liver disease (NAFLD) was diagnosed by ultrasonography and potential liver fibrosis (FIB‐4 index ≥1.3) in NAFLD was analyzed in relation to HbA1c level. Factors associated with potential liver fibrosis of NAFLD were also analyzed.
Results
The overall frequency of NAFLD was 27.9% (1935 subjects) and the frequency of NAFLD by HbA1c level ( |
| doi_str_mv | 10.1111/hepr.13282 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2126917519</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2126917519</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3812-327c09de512939ad61117693efb616873fccdc08c5396c190b1790a48c662a013</originalsourceid><addsrcrecordid>eNp9kcFqFTEUhoMotlY3PoAE3BRhak4yk0yWpVxboWApCu6GTObMvSmZyZjMtFxw0UfwGX0S095bFy48mxzIl49z8hPyFtgJ5Pq4wSmegOA1f0YOoVa8YKL8_jz3opaFFKU8IK9SumEMFOPlS3IgmJCqEuUh-bmaXIeDCz6snTWepiXe4paGnm5wCGsfWjfSU7DUjB317hYj7V0bQ3KJ5htD1zhizA-nMC3ezC6M9M7NGzqG8ff9L-Nt2ATvLO3NPG_3hs4lNAlfkxe98Qnf7M8j8u3T6uvZRXH55fzz2ellYUUNvBBcWaY7rIBroU0n89JKaoF9K0HWSvTWdpbVthJaWtCsBaWZKWsrJTcMxBE53nmnGH4smOZmcMmi92bEsKSGA5caVAU6o-__QW_CEsc8Xaa04KBEVWbqw46y-SNSxL6ZohtM3DbAmodMmodMmsdMMvxur1zaAbu_6FMIGYAdcOc8bv-jai5WV9c76R_f5pfp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2193217354</pqid></control><display><type>article</type><title>Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non‐alcoholic fatty liver disease</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Tanaka, Kenichi ; Takahashi, Hirokazu ; Hyogo, Hideyuki ; Ono, Masafumi ; Oza, Noriko ; Kitajima, Yoichiro ; Kawanaka, Miwa ; Chayama, Kazuaki ; Saibara, Toshiji ; Anzai, Keizo ; Eguchi, Yuichiro</creator><creatorcontrib>Tanaka, Kenichi ; Takahashi, Hirokazu ; Hyogo, Hideyuki ; Ono, Masafumi ; Oza, Noriko ; Kitajima, Yoichiro ; Kawanaka, Miwa ; Chayama, Kazuaki ; Saibara, Toshiji ; Anzai, Keizo ; Eguchi, Yuichiro</creatorcontrib><description>Aim
The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis‐4 (FIB‐4) index in a large general population cohort that underwent a health checkup.
Methods
A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intake were enrolled. Non‐alcoholic fatty liver disease (NAFLD) was diagnosed by ultrasonography and potential liver fibrosis (FIB‐4 index ≥1.3) in NAFLD was analyzed in relation to HbA1c level. Factors associated with potential liver fibrosis of NAFLD were also analyzed.
Results
The overall frequency of NAFLD was 27.9% (1935 subjects) and the frequency of NAFLD by HbA1c level (<4.9%, 5.0–5.9%, 6.0–6.9%, 7.0–7.9%, ≥8.0%) was 16%, 27%, 54%, 53%, and 54%, respectively. Among the 1935 NAFLD cases, the frequency of potential liver fibrosis was 25.2% (487 subjects) overall and 19%, 22%, 30%, 52%, and 31%, respectively, by HbA1c category. From multivariate analysis, an HbA1c level ≥6.5% was significantly associated with potential liver fibrosis (P = 0.017, hazard ratio = 1.7).
Conclusions
The prevalence of NAFLD and liver fibrosis of NAFLD increased according to glycemia, up to 8.0% HbA1c. Measuring HbA1c and calculating the FIB‐4 index in health checkups could help to identify potential cases of liver fibrosis of NAFLD, which should then be further evaluated using other techniques to confirm liver fibrosis.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/hepr.13282</identifier><identifier>PMID: 30367534</identifier><language>eng</language><publisher>Netherlands: Wiley Subscription Services, Inc</publisher><subject>Alcoholic beverages ; Bile ; Blood glucose ; Epidemiology ; Fatty liver ; Fibrosis ; FIB‐4 index ; health checkup ; Hemoglobin ; hemoglobin A1c ; Hepatitis B ; Liver diseases ; Multivariate analysis ; non‐alcoholic fatty liver disease ; ultrasonography ; Ultrasound</subject><ispartof>Hepatology research, 2019-03, Vol.49 (3), p.296-303</ispartof><rights>2018 The Japan Society of Hepatology</rights><rights>2018 The Japan Society of Hepatology.</rights><rights>2019 The Japan Society of Hepatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3812-327c09de512939ad61117693efb616873fccdc08c5396c190b1790a48c662a013</citedby><cites>FETCH-LOGICAL-c3812-327c09de512939ad61117693efb616873fccdc08c5396c190b1790a48c662a013</cites><orcidid>0000-0002-8433-2410</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30367534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Kenichi</creatorcontrib><creatorcontrib>Takahashi, Hirokazu</creatorcontrib><creatorcontrib>Hyogo, Hideyuki</creatorcontrib><creatorcontrib>Ono, Masafumi</creatorcontrib><creatorcontrib>Oza, Noriko</creatorcontrib><creatorcontrib>Kitajima, Yoichiro</creatorcontrib><creatorcontrib>Kawanaka, Miwa</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Saibara, Toshiji</creatorcontrib><creatorcontrib>Anzai, Keizo</creatorcontrib><creatorcontrib>Eguchi, Yuichiro</creatorcontrib><title>Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non‐alcoholic fatty liver disease</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Aim
The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis‐4 (FIB‐4) index in a large general population cohort that underwent a health checkup.
Methods
A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intake were enrolled. Non‐alcoholic fatty liver disease (NAFLD) was diagnosed by ultrasonography and potential liver fibrosis (FIB‐4 index ≥1.3) in NAFLD was analyzed in relation to HbA1c level. Factors associated with potential liver fibrosis of NAFLD were also analyzed.
Results
The overall frequency of NAFLD was 27.9% (1935 subjects) and the frequency of NAFLD by HbA1c level (<4.9%, 5.0–5.9%, 6.0–6.9%, 7.0–7.9%, ≥8.0%) was 16%, 27%, 54%, 53%, and 54%, respectively. Among the 1935 NAFLD cases, the frequency of potential liver fibrosis was 25.2% (487 subjects) overall and 19%, 22%, 30%, 52%, and 31%, respectively, by HbA1c category. From multivariate analysis, an HbA1c level ≥6.5% was significantly associated with potential liver fibrosis (P = 0.017, hazard ratio = 1.7).
Conclusions
The prevalence of NAFLD and liver fibrosis of NAFLD increased according to glycemia, up to 8.0% HbA1c. Measuring HbA1c and calculating the FIB‐4 index in health checkups could help to identify potential cases of liver fibrosis of NAFLD, which should then be further evaluated using other techniques to confirm liver fibrosis.</description><subject>Alcoholic beverages</subject><subject>Bile</subject><subject>Blood glucose</subject><subject>Epidemiology</subject><subject>Fatty liver</subject><subject>Fibrosis</subject><subject>FIB‐4 index</subject><subject>health checkup</subject><subject>Hemoglobin</subject><subject>hemoglobin A1c</subject><subject>Hepatitis B</subject><subject>Liver diseases</subject><subject>Multivariate analysis</subject><subject>non‐alcoholic fatty liver disease</subject><subject>ultrasonography</subject><subject>Ultrasound</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kcFqFTEUhoMotlY3PoAE3BRhak4yk0yWpVxboWApCu6GTObMvSmZyZjMtFxw0UfwGX0S095bFy48mxzIl49z8hPyFtgJ5Pq4wSmegOA1f0YOoVa8YKL8_jz3opaFFKU8IK9SumEMFOPlS3IgmJCqEuUh-bmaXIeDCz6snTWepiXe4paGnm5wCGsfWjfSU7DUjB317hYj7V0bQ3KJ5htD1zhizA-nMC3ezC6M9M7NGzqG8ff9L-Nt2ATvLO3NPG_3hs4lNAlfkxe98Qnf7M8j8u3T6uvZRXH55fzz2ellYUUNvBBcWaY7rIBroU0n89JKaoF9K0HWSvTWdpbVthJaWtCsBaWZKWsrJTcMxBE53nmnGH4smOZmcMmi92bEsKSGA5caVAU6o-__QW_CEsc8Xaa04KBEVWbqw46y-SNSxL6ZohtM3DbAmodMmodMmsdMMvxur1zaAbu_6FMIGYAdcOc8bv-jai5WV9c76R_f5pfp</recordid><startdate>201903</startdate><enddate>201903</enddate><creator>Tanaka, Kenichi</creator><creator>Takahashi, Hirokazu</creator><creator>Hyogo, Hideyuki</creator><creator>Ono, Masafumi</creator><creator>Oza, Noriko</creator><creator>Kitajima, Yoichiro</creator><creator>Kawanaka, Miwa</creator><creator>Chayama, Kazuaki</creator><creator>Saibara, Toshiji</creator><creator>Anzai, Keizo</creator><creator>Eguchi, Yuichiro</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8433-2410</orcidid></search><sort><creationdate>201903</creationdate><title>Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non‐alcoholic fatty liver disease</title><author>Tanaka, Kenichi ; Takahashi, Hirokazu ; Hyogo, Hideyuki ; Ono, Masafumi ; Oza, Noriko ; Kitajima, Yoichiro ; Kawanaka, Miwa ; Chayama, Kazuaki ; Saibara, Toshiji ; Anzai, Keizo ; Eguchi, Yuichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3812-327c09de512939ad61117693efb616873fccdc08c5396c190b1790a48c662a013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alcoholic beverages</topic><topic>Bile</topic><topic>Blood glucose</topic><topic>Epidemiology</topic><topic>Fatty liver</topic><topic>Fibrosis</topic><topic>FIB‐4 index</topic><topic>health checkup</topic><topic>Hemoglobin</topic><topic>hemoglobin A1c</topic><topic>Hepatitis B</topic><topic>Liver diseases</topic><topic>Multivariate analysis</topic><topic>non‐alcoholic fatty liver disease</topic><topic>ultrasonography</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Kenichi</creatorcontrib><creatorcontrib>Takahashi, Hirokazu</creatorcontrib><creatorcontrib>Hyogo, Hideyuki</creatorcontrib><creatorcontrib>Ono, Masafumi</creatorcontrib><creatorcontrib>Oza, Noriko</creatorcontrib><creatorcontrib>Kitajima, Yoichiro</creatorcontrib><creatorcontrib>Kawanaka, Miwa</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Saibara, Toshiji</creatorcontrib><creatorcontrib>Anzai, Keizo</creatorcontrib><creatorcontrib>Eguchi, Yuichiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Kenichi</au><au>Takahashi, Hirokazu</au><au>Hyogo, Hideyuki</au><au>Ono, Masafumi</au><au>Oza, Noriko</au><au>Kitajima, Yoichiro</au><au>Kawanaka, Miwa</au><au>Chayama, Kazuaki</au><au>Saibara, Toshiji</au><au>Anzai, Keizo</au><au>Eguchi, Yuichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non‐alcoholic fatty liver disease</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2019-03</date><risdate>2019</risdate><volume>49</volume><issue>3</issue><spage>296</spage><epage>303</epage><pages>296-303</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><abstract>Aim
The association between glycemia and liver fibrosis was analyzed using hemoglobin A1c (HbA1c) and the Fibrosis‐4 (FIB‐4) index in a large general population cohort that underwent a health checkup.
Methods
A total of 6927 subjects without hepatitis B or C virus infection or habitual alcohol intake were enrolled. Non‐alcoholic fatty liver disease (NAFLD) was diagnosed by ultrasonography and potential liver fibrosis (FIB‐4 index ≥1.3) in NAFLD was analyzed in relation to HbA1c level. Factors associated with potential liver fibrosis of NAFLD were also analyzed.
Results
The overall frequency of NAFLD was 27.9% (1935 subjects) and the frequency of NAFLD by HbA1c level (<4.9%, 5.0–5.9%, 6.0–6.9%, 7.0–7.9%, ≥8.0%) was 16%, 27%, 54%, 53%, and 54%, respectively. Among the 1935 NAFLD cases, the frequency of potential liver fibrosis was 25.2% (487 subjects) overall and 19%, 22%, 30%, 52%, and 31%, respectively, by HbA1c category. From multivariate analysis, an HbA1c level ≥6.5% was significantly associated with potential liver fibrosis (P = 0.017, hazard ratio = 1.7).
Conclusions
The prevalence of NAFLD and liver fibrosis of NAFLD increased according to glycemia, up to 8.0% HbA1c. Measuring HbA1c and calculating the FIB‐4 index in health checkups could help to identify potential cases of liver fibrosis of NAFLD, which should then be further evaluated using other techniques to confirm liver fibrosis.</abstract><cop>Netherlands</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30367534</pmid><doi>10.1111/hepr.13282</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8433-2410</orcidid></addata></record> |
| fulltext | fulltext |
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| ispartof | Hepatology research, 2019-03, Vol.49 (3), p.296-303 |
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| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Alcoholic beverages Bile Blood glucose Epidemiology Fatty liver Fibrosis FIB‐4 index health checkup Hemoglobin hemoglobin A1c Hepatitis B Liver diseases Multivariate analysis non‐alcoholic fatty liver disease ultrasonography Ultrasound |
| title | Epidemiological survey of hemoglobin A1c and liver fibrosis in a general population with non‐alcoholic fatty liver disease |
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