Light-Driven ATP Transmembrane Transport Controlled by DNA Nanomachines

In nature, biological machines can perform sophisticated and subtle functions to maintain the metabolism of organisms. Inspired from these gorgeous works of nature, scientists have developed various artificial molecular motors and machines. However, selective transport of biomolecules across membran...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2018-11, Vol.140 (47), p.16048-16052
Main Authors: Li, Pei, Xie, Ganhua, Liu, Pei, Kong, Xiang-Yu, Song, Yanlin, Wen, Liping, Jiang, Lei
Format: Article
Language:English
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Summary:In nature, biological machines can perform sophisticated and subtle functions to maintain the metabolism of organisms. Inspired from these gorgeous works of nature, scientists have developed various artificial molecular motors and machines. However, selective transport of biomolecules across membrane has remained a great challenge. Here, we establish an ATP transport system by assembling photocontrolled DNA nanomachines into the artificial nanochannels. With alternant light irradiation, these ATP transport lines can selectively shepherd cargoes across the polymer membrane. These findings point to new opportunities for manipulating and improving the mass transportation and separation with light-controlled biomolecular motors, and can be used for other molecules and ions transmembrane transport powered by light.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b10527