Prognostic factors in patients who received end-of-life chemotherapy for advanced cancer

Background Clinical efficacy of aggressive end-of-life (EOL) chemotherapy remains unclear. Method Medical records of patients with advanced cancer between August 2011 and August 2016 were retrospectively analyzed. The primary endpoint was to identify prognostic factors at the last administration of...

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Bibliographic Details
Published in:International journal of clinical oncology 2019-04, Vol.24 (4), p.454-459
Main Authors: Hiramoto, Shuji, Tamaki, Tomoko, Nagashima, Kengo, Hori, Tetsuo, Kikuchi, Ayako, Yoshioka, Akira, Inoue, Akira
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Cancer
Cancer Research
Chemotherapy
Decision making
Female
Humans
Kaplan-Meier Estimate
Male
Medical prognosis
Medical records
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Nausea
Nausea - chemically induced
Neoplasms - drug therapy
Neoplasms - mortality
Neoplasms - therapy
Oncology
Original Article
Patients
Prognosis
Retrospective Studies
Surgical Oncology
Terminal Care - methods
Treatment Outcome
Vomiting
Vomiting - chemically induced
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Summary:Background Clinical efficacy of aggressive end-of-life (EOL) chemotherapy remains unclear. Method Medical records of patients with advanced cancer between August 2011 and August 2016 were retrospectively analyzed. The primary endpoint was to identify prognostic factors at the last administration of chemotherapy. The secondary endpoint was to analyze the relationship between EOL symptoms and EOL treatment details. Results Among 300 evaluated patients, the number of patients who died within 14 and 30 days from the last administration of chemotherapy were 16 (5.3%) and 50 (16.7%), respectively. Multivariate analysis revealed that ECOG-PS (OR 3.698, p  
ISSN:1341-9625
1437-7772
DOI:10.1007/s10147-018-1363-7