Vitamin D Binding Protein and Vitamin D Levels in Multi-Ethnic Population

• Published in: The Journal of nutrition, health & aging health & aging, 2018-11, Vol.22 (9), p.1060-1065
• Main Authors: Merchant, Reshma A., van Dam, R. M., Tan, L. W. L., Lim, M. Y., Low, J. L., Morley, J. E.
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Aging; Bioavailability; Cross-Sectional Studies; Ethnicity; Female; Geriatrics/Gerontology; Healthy Volunteers; Humans; Male; Medicine; Medicine & Public Health; Minority & ethnic groups; Neurosciences; Nutrition; Older people; Primary Care Medicine; Quality of Life Research; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - metabolism; Vitamin D Deficiency - complications; Vitamin D-Binding Protein - pharmacology; Vitamin D-Binding Protein - therapeutic use; Vitamin deficiency
• ISSN: 1279-7707; 1760-4788
• DOI: 10.1007/s12603-018-1114-5

Introduction Low levels of 25-hydroxyvitamin D (25(OH)D) has been associated with many negative health outcomes including falls and fractures. 25(OH)D is largely bound to vitamin D binding protein (VDBP). There is increasing evidence that free or bioavailable 25(OH)D may be a better measure of vitamin D deficiency. Objective To determine the prevalence of 25(OH)D deficiency and VDBP levels in multi-ethnic population, and its impact on muscle strength. Design and methods Cross-sectional study of older adults in Western region of Singapore. 295 participants from three ethnic groups were selected from the Healthy Older People Everyday (HOPE) cohort for measurements of total 25(OH)D and VDBP levels. Total 25(OH)D, VDBP, frailty status, Timed-Up-and-Go (TUG) and grip strength (GS) were assessed. Albumin, free and bioavailable 25(OH)D were only available for 256 participants. Results 53% of Malay and 55% of Indians were deficient in 25(OH)D compared with 18.2% of ethnic Chinese participants. Chinese also had higher total 25(OH)D concentrations with a mean of 29.1 ug/l, (p =