Highly active fluorogenic oxidase-mimicking NiO nanozymes

Oxidase-mimicking nanozymes are attractive since they do not require H 2 O 2 , but such examples are quite rare. In particular, few can catalyze oxidation of fluorogenic substrates. We herein communicate that NiO nanoparticles are an oxidase nanozyme at physiological pH for fluorogenic Amplex red. I...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-11, Vol.54 (88), p.12519-12522
Main Authors: Li, Dai, Liu, Biwu, Huang, Po-Jung Jimmy, Zhang, Zijie, Liu, Juewen
Format: Article
Language:English
Subjects:
Biosensors
Hydrogen peroxide
Nanoparticles
Nickel oxides
Oxidase
Oxidation
Substrates
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Summary:Oxidase-mimicking nanozymes are attractive since they do not require H 2 O 2 , but such examples are quite rare. In particular, few can catalyze oxidation of fluorogenic substrates. We herein communicate that NiO nanoparticles are an oxidase nanozyme at physiological pH for fluorogenic Amplex red. Its activity is much higher than that of the commonly used nanoceria. This finding fills an urgent gap for biosensor development and intracellular imaging for the nanozyme field. NiO nanoparticles can quickly catalyze oxidation of Amplex red to produce fluorescent products for intracellular imaging, much more efficiently than other types of tested nanozymes.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07062h