Effects of oral ısotretinoin on normal and wounded nasal mucosa: an experimental study

Background We aimed to investigate the effect of systemic isotretinoin therapy on normal and wounded nasal septal mucosa histopathologically in an experimental rabbit model. Methods Circular mucosal defect with a 7 mm diameter was made in the left septum of 12 New Zealand white rabbits. The rabbits...

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Published in:European archives of oto-rhino-laryngology 2018-12, Vol.275 (12), p.3025-3031
Main Authors: Cengiz, Abdurrahman Bugra, Ozyilmaz, Cemal, Tabaru, Alper, Kayabasi, Serkan, Ege, Sertug Sinan, Ruzgar, Sedat, Emre, Funda, Oktay, Mehmet Faruk
Format: Article
Language:English
Subjects:
Animals
Cell Count
Cilia - drug effects
Cilia - pathology
Cilia - physiology
Dermatologic Agents - pharmacology
Goblet Cells - drug effects
Goblet Cells - physiology
Head and Neck Surgery
Inflammation - pathology
Isotretinoin - pharmacology
Male
Medicine
Medicine & Public Health
Nasal Mucosa - drug effects
Nasal Mucosa - injuries
Nasal Mucosa - pathology
Nasal Mucosa - physiopathology
Nasal Septum - surgery
Neurosurgery
Otorhinolaryngology
Rabbits
Regeneration - drug effects
Rhinology
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Summary:Background We aimed to investigate the effect of systemic isotretinoin therapy on normal and wounded nasal septal mucosa histopathologically in an experimental rabbit model. Methods Circular mucosal defect with a 7 mm diameter was made in the left septum of 12 New Zealand white rabbits. The rabbits were divided into two groups (six rabbits in each group) oral isotretinoin was given with olive oil at the operation day to the first group. The control group was only oil given group. The harvested septum mucosas were divided into four groups (1—wounded-drug given side, 2—unwounded and drug-given side, 3—wounded-control and 4—unwounded-control side). The diameter of the defect, mucosal thickness, epithelial thickness, ciliated cell level, goblet cell level and inflammation were evaluated every week for 4 weeks. Results At both wounded and normal side, thinning of normal respiratory ciliated epithelium was observed in the postoperative period. In study group at the wounded side; mean mucosal thickness was measured 139.66 µ (± 26.24), and in the control group, mean mucosal thickness was 238.33 µ (± 39.7) at the wounded side. ( p  
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-018-5190-2