Detection of virulent strains of Helicobacter pylori and its relation to symptoms and signs in children

<正>Objective:To detect the prevalence of Helicobacter polori(H.pylori) in a group of pediatric patients complaining of gastrointestinal disorders,and to identify the virulent strains of H. pylori and its relation to peptic disease.Methods:The study included 60 patients(41 males and 19...

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Published in:Asian Pacific journal of tropical medicine 2010, Vol.3 (1), p.59-62
Main Authors: Fayed, S, Abd El Dayem, S, Hussein, H, Sherief, M, El–Naghi, S
Format: Article
Language:English
Subjects:
antibody
disorder
Gastrointestinal
Gastrointestinal disorder
Helicobacter
Helicobacter pylori
IgG
IgG antibody
Pediatric
pylori
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Summary:<正>Objective:To detect the prevalence of Helicobacter polori(H.pylori) in a group of pediatric patients complaining of gastrointestinal disorders,and to identify the virulent strains of H. pylori and its relation to peptic disease.Methods:The study included 60 patients(41 males and 19 females),aged from 6 months to 14 years,with complaining of different gastrointestinal troubles.Anti-H.pylori IgG antibodies were used.Thorough examination of the oesophagus, stomach and duodenum was done in all patients using a fibreoptic endoscopy.In addition, gastric antral biopsies were taken for diagnosis of H.pylori infection in the following test: rapid urease test,histopathologic examination and culture.And cytotoxin assay of virulent strains was employed.H.pylori infection was diagnosed if 3 or more tests for diagnosis were found to be positive.Results:33 out of 60 patients(55%) was positive.12(20%) patients had positive toxin producing strains(virulent strains).Virulent strain had a significantly closer relationship with recurrent abdominal pain,while no difference was found in other symptoms. Age of patients showed a highly significant positive correlation with virulent H.pylori strain. Histopathological finding revealed that oesophagitis was significandy common in patients with negative H.pylori.Endoscopy and histopathological findings revealed that virulent strain had a significandy higher gastritis and oesophagitis rates.Conclusion:Infection by virulent strains of H.pylori in children is not uncommon:It is associated with endoscopic and histopathologic changes.All cases infected with virulent strain showed positive results by using rapid urease test,culture and IgG antibodies.
ISSN:1995-7645
2352-4146
DOI:10.1016/S1995-7645(10)60034-X