Hypothyroidism Induced by Polychlorinated Biphenyls and Up-Regulation of Transthyretin

Polychlorinated biphenyls are environmental pollutants that are toxic to many biological systems. This study examined whether or not PCB126 and PCB114 have adverse effects on the serum thyroxine level and the serum proteome in rats. The results showed a lower serum total thyroxine level in the PCB12...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 2010, Vol.84 (1), p.66-70
Main Authors: Han, Dae-Yong, Kang, Sang-Rim, Park, Oh-Sung, Cho, Jae-Hyeon, Won, Chung-Kil, Park, Hyeon-Soo, Park, Kwang-Il, Kim, Eun-Hee, Kim, Gon-Sup
Format: Article
Language:English
Subjects:
Animals
Aquatic Pollution
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Hypothyroidism - chemically induced
Male
PCB
Pollution
Polychlorinated biphenyls
Polychlorinated Biphenyls - toxicity
Prealbumin - genetics
Prealbumin - metabolism
Proteomics
Rats
Rats, Sprague-Dawley
Rodents
Soil Science & Conservation
Thyroid diseases
Thyroxine - blood
Toxicology
Up-Regulation - drug effects
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Polychlorinated biphenyls are environmental pollutants that are toxic to many biological systems. This study examined whether or not PCB126 and PCB114 have adverse effects on the serum thyroxine level and the serum proteome in rats. The results showed a lower serum total thyroxine level in the PCB126 and PCB114-treated groups than the control. Western blotting showed that the levels of transthyretin expression were significantly higher in the PCB-treated group than the control group. These results suggest that the PCB-mediated hypothyroidism is caused by the displacement of thyroxine from transthyretin.
ISSN:0007-4861
1432-0800
DOI:10.1007/s00128-009-9890-6