A review of biomonitoring studies measuring genotoxicity in humans exposed to hair dyes

Hair dye ingredients frequently produce positive results in short-term in vitro genotoxicity tests, although results from in vivo assays are typically negative, especially for ingredients in use today. The use of hair dyes is quite widespread resulting in the exposure both for persons working in hai...

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Bibliographic Details
Published in:Mutagenesis 2010-01, Vol.25 (1), p.17-23
Main Authors: Preston, R. Julian, Skare, Julie A., Aardema, Marilyn J.
Format: Article
Language:English
Subjects:
Biological and medical sciences
DNA Damage - genetics
Environmental Monitoring - statistics & numerical data
Fundamental and applied biological sciences. Psychology
Hair Dyes - toxicity
Humans
Molecular and cellular biology
Molecular genetics
Mutagenesis. Repair
Mutagenicity Tests - statistics & numerical data
New York
Occupational Exposure - statistics & numerical data
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Summary:Hair dye ingredients frequently produce positive results in short-term in vitro genotoxicity tests, although results from in vivo assays are typically negative, especially for ingredients in use today. The use of hair dyes is quite widespread resulting in the exposure both for persons working in hairdressing salons and for individuals who have their hair dyed. This provides the opportunity to add to the data from standard in vitro and in vivo genotoxicity tests by investigating whether or not genotoxic responses are detected in such exposed individuals. A number of biomonitoring studies of humans exposed to hair dyes have been conducted using either cytogenetic alterations or DNA damage as measures of genotoxicity, or urine mutagenicity as a measure of exposure to genotoxic compounds. In this paper, each study is critically reviewed and interpreted. Overall, there is no consistent evidence of genotoxicity in humans exposed to hair dyes occupationally or through individual use.
ISSN:0267-8357
1464-3804
DOI:10.1093/mutage/gep044