High‐dose preoperative cholecalciferol to prevent post‐thyroidectomy hypocalcaemia: A randomized, double‐blinded placebo‐controlled trial

Summary Objective Post‐thyroidectomy hypocalcaemia is a significant cause of morbidity and prolonged hospitalization, usually due to transient parathyroid gland damage, treated with calcium and vitamin D supplementation. We present a randomized, double‐blinded placebo‐controlled trial of preoperativ...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2019-02, Vol.90 (2), p.343-350
Main Authors: Rowe, Christopher W., Arthurs, Sam, O’Neill, Christine J., Hawthorne, Jacqueline, Carroll, Rosemary, Wynne, Katie, Bendinelli, Cino
Format: Article
Language:English
Subjects:
Adult
Calcium
Calcium-Regulating Hormones and Agents - therapeutic use
cholecalciferol
Cholecalciferol - administration & dosage
Cholecalciferol - therapeutic use
Female
Graves' disease
Humans
hypocalcaemia
Hypocalcemia
Hypocalcemia - etiology
Hypocalcemia - prevention & control
Male
Malignancy
Middle Aged
Morbidity
Parathyroid
Parathyroid hormone
Patients
Premedication - methods
Preoperative Care - methods
RCT
Supplements
Surgery
Thyroidectomy
Thyroidectomy - adverse effects
Treatment Outcome
Vitamin D
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Summary:Summary Objective Post‐thyroidectomy hypocalcaemia is a significant cause of morbidity and prolonged hospitalization, usually due to transient parathyroid gland damage, treated with calcium and vitamin D supplementation. We present a randomized, double‐blinded placebo‐controlled trial of preoperative loading with high‐dose cholecalciferol (300 000 IU) to reduce post‐thyroidectomy hypocalcaemia. Patients and Measurements Patients (n = 160) presenting for thyroidectomy at tertiary hospitals were randomized 1:1 to cholecalciferol (300 000 IU) or placebo 7 days prior to thyroidectomy. Ten patients withdrew prior to surgery. The primary outcome was post‐operative hypocalcaemia (corrected calcium
ISSN:0300-0664
1365-2265
DOI:10.1111/cen.13897