A novel protocol for initial heparin administration during catheter ablation for atrial fibrillation in patients taking direct oral anticoagulants

Thromboembolism and bleeding complications remain a major limitation of the catheter ablation (CA) for atrial fibrillation (AF). This study aimed to evaluate the association between achieving target activated clotting time (ACT) and clinical factors, and to develop an appropriate protocol for early...

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Bibliographic Details
Published in:Heart and vessels 2019-05, Vol.34 (5), p.832-841
Main Authors: Kishima, Hideyuki, Mine, Takanao, Fukuhara, Eiji, Ashida, Kenki, Ishihara, Masaharu, Masuyama, Tohru
Format: Article
Language:English
Subjects:
Ablation
Anticoagulants
Biomedical Engineering and Bioengineering
Bleeding
Cardiac arrhythmia
Cardiac Surgery
Cardiology
Catheters
Clotting
Complications
Echocardiography
Fibrillation
Heparin
Males
Medical instruments
Medicine
Medicine & Public Health
Multivariate analysis
Original Article
Patients
Radiofrequency ablation
Thromboembolism
Vascular Surgery
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Summary:Thromboembolism and bleeding complications remain a major limitation of the catheter ablation (CA) for atrial fibrillation (AF). This study aimed to evaluate the association between achieving target activated clotting time (ACT) and clinical factors, and to develop an appropriate protocol for early achievement of target ACT in patients with direct oral anticoagulants (DOACs). At the initiation cohort, 190 patients (127 males, age 68 ± 9) taking DOACs who underwent CA for AF were studied. All patients underwent transthoracic echocardiography/transesophageal echocardiography/blood sampling before the CA. The ACTs were measured before heparin administration (pre-ACT) and in 30 min (30-min ACT) after initial heparin administration (100 U/kg +3000 U). At the validation cohort, the indicator obtained from the first study was reassessed in the subsequent 138 patients (94 males, age 68 ± 10). At the initiation cohort, 30-min ACT reached the target ACT in 79/190 patients (42%). Univariate analysis showed that longer pre-ACT, elevated aPTT, higher PT-INR, antiplatelet medication, and dabigatran were associated with achieving the target 30-min ACT. On multivariate analysis, only longer pre-ACT was independently associated with achieving the target 30-min ACT ( P  = 0.0396, the optimal cutoff value; 130 s). As a novel protocol, we added 2000 U of initial heparin dose (total 100 U/kg +5000 U) in patients with low pre-ACT (
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-018-1294-2