Dephasing optimization through coherence order pathway selection (DOTCOPS) for improved crusher schemes in MR spectroscopy

Purpose To develop an algorithm which can robustly eliminate all unwanted coherence pathways for an arbitrary magnetic resonance spectroscopy experiment through the adjustment of the relative amplitudes of crusher gradients, thereby reducing the effects of spurious echoes and mislocalization. Theory...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2019-04, Vol.81 (4), p.2209-2222
Main Authors: Landheer, Karl, Juchem, Christoph
Format: Article
Language:English
Subjects:
Algorithms
Coherence
coherence order
coherence pathway selection
Computer Simulation
crusher schemes
Crushing
Diffusion
Echoes
Healthy Volunteers
Humans
Image Processing, Computer-Assisted - methods
In vivo methods and tests
in vivo spectroscopy
Magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy - methods
Male
MRS
Normal Distribution
Optimization
Phantoms, Imaging
phase cycling
Radio Waves
Resonance
Software
Spectrophotometry
Spectroscopy
Spectrum analysis
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Summary:Purpose To develop an algorithm which can robustly eliminate all unwanted coherence pathways for an arbitrary magnetic resonance spectroscopy experiment through the adjustment of the relative amplitudes of crusher gradients, thereby reducing the effects of spurious echoes and mislocalization. Theory and Methods The effect of crushing gradients for all coherence pathways was modeled according to the associated physics, and a cost function was optimized which maximally crushes all unwanted coherence pathways, while unaffecting the desired coherence pathway(s). The efficacy of the method was tested versus literature schemes from 2 separate MR spectroscopy (MRS) sequences: sLASER and MEGA‐sLASER with both phantom and in vivo experiments. Results Improved crushing power for 2 separate MRS sequences was demonstrated for 2 crushing schemes adopted from the literature in both phantom and in vivo data. Conclusion A novel algorithm and associated software was developed based on rigorous treatment of all coherence pathways, which can be applied to any arbitrary magnetic resonance spectroscopic pulse sequence of interest and any arbitrary coupled spin system. This developed method solves a long‐standing problem in in vivo MRS and is expected to critically improve the data quality of virtually all MRS applications.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.27587