Myelin water fraction changes in febrile seizures

•Myelin water fraction (MWF) maps could be used to further characterize febrile seizures.•All subjects in this study with simple febrile seizures had increased MWF.•All subjects in this study with complex febrile seizures had decreased MWF. The objective of this feasibility study was to investigate...

Full description

Saved in:
Bibliographic Details
Published in:Clinical neurology and neurosurgery 2018-12, Vol.175, p.61-67
Main Authors: Moldovan, Krisztina, Boxerman, Jerrold L., O’Muircheartaigh, Jonathan, Dean, Doug, Eyerly-Webb, Stephanie, Cosgrove, G. Rees, Pucci, Francesco G., Deoni, Sean C.L., Spader, Heather S.
Format: Article
Language:English
Subjects:
Age
Children
Convulsions & seizures
Epilepsy
Feasibility studies
febrile
Fever
Magnetic resonance imaging
Myelin
Myelination
Neurology
NMR
Nuclear magnetic resonance
Patients
Pediatrics
Risk factors
Seizing
Seizures
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Myelin water fraction (MWF) maps could be used to further characterize febrile seizures.•All subjects in this study with simple febrile seizures had increased MWF.•All subjects in this study with complex febrile seizures had decreased MWF. The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not. As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences—T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)—and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas. All seven subjects (
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2018.10.005