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Myelin water fraction changes in febrile seizures
•Myelin water fraction (MWF) maps could be used to further characterize febrile seizures.•All subjects in this study with simple febrile seizures had increased MWF.•All subjects in this study with complex febrile seizures had decreased MWF. The objective of this feasibility study was to investigate...
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| Published in: | Clinical neurology and neurosurgery 2018-12, Vol.175, p.61-67 |
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| container_title | Clinical neurology and neurosurgery |
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| creator | Moldovan, Krisztina Boxerman, Jerrold L. O’Muircheartaigh, Jonathan Dean, Doug Eyerly-Webb, Stephanie Cosgrove, G. Rees Pucci, Francesco G. Deoni, Sean C.L. Spader, Heather S. |
| description | •Myelin water fraction (MWF) maps could be used to further characterize febrile seizures.•All subjects in this study with simple febrile seizures had increased MWF.•All subjects in this study with complex febrile seizures had decreased MWF.
The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not.
As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences—T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)—and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas.
All seven subjects ( |
| doi_str_mv | 10.1016/j.clineuro.2018.10.005 |
| format | article |
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The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not.
As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences—T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)—and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas.
All seven subjects (<5 years old) initially presented with febrile seizures. Of the seven, four had complex seizures and three had simple seizures. All of the children with simple febrile seizures had higher MWF compared with model-derived controls and did not develop epilepsy. All of the children with complex febrile seizures had lower MWF than their model-derived control, and two of these subjects later developed epilepsy.
This is the first study in which MWF maps were used to study children with febrile *seizures. This data suggests that relatively higher or stable MWF compared with normative data indicates a lower risk of nonfebrile epilepsy while relatively lower MWF may indicate a pathological condition that could lead to nonfebrile epilepsy.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2018.10.005</identifier><identifier>PMID: 30384118</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Age ; Children ; Convulsions & seizures ; Epilepsy ; Feasibility studies ; febrile ; Fever ; Magnetic resonance imaging ; Myelin ; Myelination ; Neurology ; NMR ; Nuclear magnetic resonance ; Patients ; Pediatrics ; Risk factors ; Seizing ; Seizures</subject><ispartof>Clinical neurology and neurosurgery, 2018-12, Vol.175, p.61-67</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-feae7ca1c22df62a068cfed30ca619aaf65fa616ad99d112b47aaf476081605a3</citedby><cites>FETCH-LOGICAL-c444t-feae7ca1c22df62a068cfed30ca619aaf65fa616ad99d112b47aaf476081605a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30384118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moldovan, Krisztina</creatorcontrib><creatorcontrib>Boxerman, Jerrold L.</creatorcontrib><creatorcontrib>O’Muircheartaigh, Jonathan</creatorcontrib><creatorcontrib>Dean, Doug</creatorcontrib><creatorcontrib>Eyerly-Webb, Stephanie</creatorcontrib><creatorcontrib>Cosgrove, G. Rees</creatorcontrib><creatorcontrib>Pucci, Francesco G.</creatorcontrib><creatorcontrib>Deoni, Sean C.L.</creatorcontrib><creatorcontrib>Spader, Heather S.</creatorcontrib><title>Myelin water fraction changes in febrile seizures</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>•Myelin water fraction (MWF) maps could be used to further characterize febrile seizures.•All subjects in this study with simple febrile seizures had increased MWF.•All subjects in this study with complex febrile seizures had decreased MWF.
The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not.
As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences—T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)—and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas.
All seven subjects (<5 years old) initially presented with febrile seizures. Of the seven, four had complex seizures and three had simple seizures. All of the children with simple febrile seizures had higher MWF compared with model-derived controls and did not develop epilepsy. All of the children with complex febrile seizures had lower MWF than their model-derived control, and two of these subjects later developed epilepsy.
This is the first study in which MWF maps were used to study children with febrile *seizures. This data suggests that relatively higher or stable MWF compared with normative data indicates a lower risk of nonfebrile epilepsy while relatively lower MWF may indicate a pathological condition that could lead to nonfebrile epilepsy.</description><subject>Age</subject><subject>Children</subject><subject>Convulsions & seizures</subject><subject>Epilepsy</subject><subject>Feasibility studies</subject><subject>febrile</subject><subject>Fever</subject><subject>Magnetic resonance imaging</subject><subject>Myelin</subject><subject>Myelination</subject><subject>Neurology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Risk factors</subject><subject>Seizing</subject><subject>Seizures</subject><issn>0303-8467</issn><issn>1872-6968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkL1OwzAURi0EoqXwClUkFpYE39hxnA1U8ScVscBsuc41uEqTYieg8vS4amFgYbL1-dzvWoeQKdAMKIjLZWYa1-LguyynIGOYUVockDHIMk9FJeQhGVNGWSq5KEfkJIQlpZQxIY_JKOaSA8gxgccNxqLkU_foE-u16V3XJuZNt68YkvhiceFdg0lA9zV4DKfkyOom4Nn-nJCX25vn2X06f7p7mF3PU8M571OLGkujweR5bUWuqZDGYs2o0QIqra0obLwJXVdVDZAveBlDXgoqQdBCswm52PWuffc-YOjVygWDTaNb7IagcsirgkngIqLnf9BlN_g2_i5SrAQoOSsiJXaU8V0IHq1ae7fSfqOAqq1UtVQ_UtVW6jaPUuPgdF8_LFZY_479WIzA1Q7A6OPDoVfBOGwN1s6j6VXduf92fAMFg4ru</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Moldovan, Krisztina</creator><creator>Boxerman, Jerrold L.</creator><creator>O’Muircheartaigh, Jonathan</creator><creator>Dean, Doug</creator><creator>Eyerly-Webb, Stephanie</creator><creator>Cosgrove, G. Rees</creator><creator>Pucci, Francesco G.</creator><creator>Deoni, Sean C.L.</creator><creator>Spader, Heather S.</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>Myelin water fraction changes in febrile seizures</title><author>Moldovan, Krisztina ; Boxerman, Jerrold L. ; O’Muircheartaigh, Jonathan ; Dean, Doug ; Eyerly-Webb, Stephanie ; Cosgrove, G. Rees ; Pucci, Francesco G. ; Deoni, Sean C.L. ; Spader, Heather S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-feae7ca1c22df62a068cfed30ca619aaf65fa616ad99d112b47aaf476081605a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Children</topic><topic>Convulsions & seizures</topic><topic>Epilepsy</topic><topic>Feasibility studies</topic><topic>febrile</topic><topic>Fever</topic><topic>Magnetic resonance imaging</topic><topic>Myelin</topic><topic>Myelination</topic><topic>Neurology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Risk factors</topic><topic>Seizing</topic><topic>Seizures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moldovan, Krisztina</creatorcontrib><creatorcontrib>Boxerman, Jerrold L.</creatorcontrib><creatorcontrib>O’Muircheartaigh, Jonathan</creatorcontrib><creatorcontrib>Dean, Doug</creatorcontrib><creatorcontrib>Eyerly-Webb, Stephanie</creatorcontrib><creatorcontrib>Cosgrove, G. 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Rees</au><au>Pucci, Francesco G.</au><au>Deoni, Sean C.L.</au><au>Spader, Heather S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myelin water fraction changes in febrile seizures</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><addtitle>Clin Neurol Neurosurg</addtitle><date>2018-12</date><risdate>2018</risdate><volume>175</volume><spage>61</spage><epage>67</epage><pages>61-67</pages><issn>0303-8467</issn><eissn>1872-6968</eissn><abstract>•Myelin water fraction (MWF) maps could be used to further characterize febrile seizures.•All subjects in this study with simple febrile seizures had increased MWF.•All subjects in this study with complex febrile seizures had decreased MWF.
The objective of this feasibility study was to investigate whether myelin water fraction (MWF) patterns can differentiate children presenting with febrile seizures who will go on to develop nonfebrile epilepsy from those who will not.
As part of a prospective study of myelination patterns in pediatric epilepsy, seven subjects with febrile seizures underwent magnetic resonance imaging (MRI) including the following standard sequences—T1-weighted, T2-weighted, fluid-attenuated inversion recovery (FLAIR)—and an additional experimental sequence, multicomponent-derived equilibrium single-pulse observation of T1 and T2 (mcDESPOT) to quantify MWF. For each of these subjects, MWF maps were derived and compared with an age-matched population-averaged MWF atlas.
All seven subjects (<5 years old) initially presented with febrile seizures. Of the seven, four had complex seizures and three had simple seizures. All of the children with simple febrile seizures had higher MWF compared with model-derived controls and did not develop epilepsy. All of the children with complex febrile seizures had lower MWF than their model-derived control, and two of these subjects later developed epilepsy.
This is the first study in which MWF maps were used to study children with febrile *seizures. This data suggests that relatively higher or stable MWF compared with normative data indicates a lower risk of nonfebrile epilepsy while relatively lower MWF may indicate a pathological condition that could lead to nonfebrile epilepsy.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>30384118</pmid><doi>10.1016/j.clineuro.2018.10.005</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elsevier |
| subjects | Age Children Convulsions & seizures Epilepsy Feasibility studies febrile Fever Magnetic resonance imaging Myelin Myelination Neurology NMR Nuclear magnetic resonance Patients Pediatrics Risk factors Seizing Seizures |
| title | Myelin water fraction changes in febrile seizures |
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