Antimalarial compounds from Schefflera umbellifera

The organic extract of the leaves of Schefflera umbellifera exhibited good antimalarial activity when tested against the chloroquine-susceptible strain (D10). Bioassay-guided fractionation of the dichloromethane fraction of the dichloromethane/methanol extract yielded an active compound, betulin, wh...

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Bibliographic Details
Published in:South African journal of botany 2010, Vol.76 (1), p.82-85
Main Authors: Mthembu, X.S., Van Heerden, F.R., Fouché, G.
Format: Article
Language:English
Subjects:
Antiplasmodial activity
Betulin
ent-kaur-16-en-19-oic acid
Plasmodium falciparum
Schefflera
Schefflera umbellifera
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Summary:The organic extract of the leaves of Schefflera umbellifera exhibited good antimalarial activity when tested against the chloroquine-susceptible strain (D10). Bioassay-guided fractionation of the dichloromethane fraction of the dichloromethane/methanol extract yielded an active compound, betulin, which exhibited good antiplasmodial activity with an IC 50 value of 3.2 µg/ml. The reference compound, chloroquine gave an IC 50 value of 27.2 ng/ml. Two other compounds were also isolated from the dichloromethane extract namely, 7-hydroxy-6-methoxycoumarin and ent-kaur-16-en-19-oic acid. These two compounds did not exhibit any significant antiplasmodial activity.
ISSN:0254-6299
1727-9321
DOI:10.1016/j.sajb.2009.07.019