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Topography of a Visuomotor Transformation
The brain converts perceptual information into appropriate patterns of muscle activity depending on the categorization and localization of sensory cues. Sensorimotor information might either be encoded by distributed networks or by “labeled lines” connecting sensory channels to dedicated behavioral...
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Published in: | Neuron (Cambridge, Mass.) Mass.), 2018-12, Vol.100 (6), p.1429-1445.e4 |
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creator | Helmbrecht, Thomas O. dal Maschio, Marco Donovan, Joseph C. Koutsouli, Styliani Baier, Herwig |
description | The brain converts perceptual information into appropriate patterns of muscle activity depending on the categorization and localization of sensory cues. Sensorimotor information might either be encoded by distributed networks or by “labeled lines” connecting sensory channels to dedicated behavioral pathways. Here we investigate, in the context of natural behavior, how the tectum of larval zebrafish can inform downstream premotor areas. Optogenetic mapping revealed a tectal motor map underlying locomotor maneuvers for escape and approach. Single-cell reconstructions and high-resolution functional imaging showed that two spatially segregated and uncrossed descending axon tracts selectively transmit approach and escape signals to the hindbrain. Moreover, the approach pathway conveys information about retinotopic target coordinates to specific premotor ensembles via spatially ordered axonal projections. This topographic organization supports a tectum-generated space code sufficient to steer orienting movements. We conclude that specific labeled lines guide object-directed behavior in the larval zebrafish brain.
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•The tectal motor map in zebrafish larvae is topographically organized•A cellular resolution anatomical atlas of tectal projection neurons is generated•Segregated tectal output pathways convey looming/dimming and prey-likeinformation•Retinotopically organized tectal projections relay prey location to the hindbrain
Helmbrecht et al. identify neural pathways connecting the tectum to target areas. Combining optogenetics, imaging, and single-cell reconstructions, they assign behavioral functions to distinct classes of projection neurons conveying information about valence and location of visual objects to premotor circuits. |
doi_str_mv | 10.1016/j.neuron.2018.10.021 |
format | article |
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[Display omitted]
•The tectal motor map in zebrafish larvae is topographically organized•A cellular resolution anatomical atlas of tectal projection neurons is generated•Segregated tectal output pathways convey looming/dimming and prey-likeinformation•Retinotopically organized tectal projections relay prey location to the hindbrain
Helmbrecht et al. identify neural pathways connecting the tectum to target areas. Combining optogenetics, imaging, and single-cell reconstructions, they assign behavioral functions to distinct classes of projection neurons conveying information about valence and location of visual objects to premotor circuits.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2018.10.021</identifier><identifier>PMID: 30392799</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Axon guidance ; Cluster analysis ; Danio rerio ; Hindbrain ; Localization ; motor map ; Neuroimaging ; Neurons ; optic tectum ; optogenetics ; reticular formation ; Retina ; Sensorimotor integration ; Sensorimotor system ; Software ; space code ; superior colliculus ; Swimming ; tectal projectome ; Tectum ; Topography ; visuomotor transformation ; zebrafish</subject><ispartof>Neuron (Cambridge, Mass.), 2018-12, Vol.100 (6), p.1429-1445.e4</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 19, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-b4e8d80c367d97df139fe710baeec9e35c6e304bc0d84af8fc5e1dfe46342fbb3</citedby><cites>FETCH-LOGICAL-c436t-b4e8d80c367d97df139fe710baeec9e35c6e304bc0d84af8fc5e1dfe46342fbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30392799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Helmbrecht, Thomas O.</creatorcontrib><creatorcontrib>dal Maschio, Marco</creatorcontrib><creatorcontrib>Donovan, Joseph C.</creatorcontrib><creatorcontrib>Koutsouli, Styliani</creatorcontrib><creatorcontrib>Baier, Herwig</creatorcontrib><title>Topography of a Visuomotor Transformation</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>The brain converts perceptual information into appropriate patterns of muscle activity depending on the categorization and localization of sensory cues. Sensorimotor information might either be encoded by distributed networks or by “labeled lines” connecting sensory channels to dedicated behavioral pathways. Here we investigate, in the context of natural behavior, how the tectum of larval zebrafish can inform downstream premotor areas. Optogenetic mapping revealed a tectal motor map underlying locomotor maneuvers for escape and approach. Single-cell reconstructions and high-resolution functional imaging showed that two spatially segregated and uncrossed descending axon tracts selectively transmit approach and escape signals to the hindbrain. Moreover, the approach pathway conveys information about retinotopic target coordinates to specific premotor ensembles via spatially ordered axonal projections. This topographic organization supports a tectum-generated space code sufficient to steer orienting movements. We conclude that specific labeled lines guide object-directed behavior in the larval zebrafish brain.
[Display omitted]
•The tectal motor map in zebrafish larvae is topographically organized•A cellular resolution anatomical atlas of tectal projection neurons is generated•Segregated tectal output pathways convey looming/dimming and prey-likeinformation•Retinotopically organized tectal projections relay prey location to the hindbrain
Helmbrecht et al. identify neural pathways connecting the tectum to target areas. 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dal Maschio, Marco ; Donovan, Joseph C. ; Koutsouli, Styliani ; Baier, Herwig</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-b4e8d80c367d97df139fe710baeec9e35c6e304bc0d84af8fc5e1dfe46342fbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Axon guidance</topic><topic>Cluster analysis</topic><topic>Danio rerio</topic><topic>Hindbrain</topic><topic>Localization</topic><topic>motor map</topic><topic>Neuroimaging</topic><topic>Neurons</topic><topic>optic tectum</topic><topic>optogenetics</topic><topic>reticular formation</topic><topic>Retina</topic><topic>Sensorimotor integration</topic><topic>Sensorimotor system</topic><topic>Software</topic><topic>space code</topic><topic>superior colliculus</topic><topic>Swimming</topic><topic>tectal projectome</topic><topic>Tectum</topic><topic>Topography</topic><topic>visuomotor transformation</topic><topic>zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Helmbrecht, Thomas O.</creatorcontrib><creatorcontrib>dal Maschio, Marco</creatorcontrib><creatorcontrib>Donovan, Joseph C.</creatorcontrib><creatorcontrib>Koutsouli, Styliani</creatorcontrib><creatorcontrib>Baier, Herwig</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Helmbrecht, Thomas O.</au><au>dal Maschio, Marco</au><au>Donovan, Joseph C.</au><au>Koutsouli, Styliani</au><au>Baier, Herwig</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Topography of a Visuomotor Transformation</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2018-12-19</date><risdate>2018</risdate><volume>100</volume><issue>6</issue><spage>1429</spage><epage>1445.e4</epage><pages>1429-1445.e4</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>The brain converts perceptual information into appropriate patterns of muscle activity depending on the categorization and localization of sensory cues. 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[Display omitted]
•The tectal motor map in zebrafish larvae is topographically organized•A cellular resolution anatomical atlas of tectal projection neurons is generated•Segregated tectal output pathways convey looming/dimming and prey-likeinformation•Retinotopically organized tectal projections relay prey location to the hindbrain
Helmbrecht et al. identify neural pathways connecting the tectum to target areas. Combining optogenetics, imaging, and single-cell reconstructions, they assign behavioral functions to distinct classes of projection neurons conveying information about valence and location of visual objects to premotor circuits.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30392799</pmid><doi>10.1016/j.neuron.2018.10.021</doi><oa>free_for_read</oa></addata></record> |
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subjects | Axon guidance Cluster analysis Danio rerio Hindbrain Localization motor map Neuroimaging Neurons optic tectum optogenetics reticular formation Retina Sensorimotor integration Sensorimotor system Software space code superior colliculus Swimming tectal projectome Tectum Topography visuomotor transformation zebrafish |
title | Topography of a Visuomotor Transformation |
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