Effect of renal ischemia on urinary excretion of lithium in rats

Lithium, administered to patients with bipolar disorders, is mainly excreted in the urine, and tubular reabsorption is involved. This study characterized the renal excretion of lithium in rats subjected to renal ischemia for 60 min or 90 min. After intravenous injection of lithium chloride at 25 mg/...

Full description

Saved in:
Bibliographic Details
Published in:Biopharmaceutics & drug disposition 2018-11, Vol.39 (9), p.448-451
Main Authors: Uwai, Yuichi, Suzuki, Takato, Kondo, Ryota, Kawasaki, Tatsuya, Nabekura, Tomohiro
Format: Article
Language:English
Subjects:
Animals
Antimanic Agents - pharmacokinetics
Creatinine
Disease Models, Animal
Excretion
fractional excretion
Hydrogen-Ion Concentration
Injections, Intravenous
Intravenous administration
Ischemia
Ischemia - complications
Kidney - blood supply
Kidney - metabolism
Kidneys
Linear Models
Lithium
Lithium chloride
Lithium Chloride - pharmacokinetics
Male
Rats
Rats, Wistar
Reabsorption
Renal function
renal ischemia
Rodents
Time Factors
Urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lithium, administered to patients with bipolar disorders, is mainly excreted in the urine, and tubular reabsorption is involved. This study characterized the renal excretion of lithium in rats subjected to renal ischemia for 60 min or 90 min. After intravenous injection of lithium chloride at 25 mg/kg, the pharmacokinetic parameters of lithium were determined. In sham‐operated rats, the renal clearance of lithium was calculated to be 1.49 ml/min/kg, and its ratio to creatinine clearance (fractional excretion) was 43.4%. Renal ischemia inhibited the renal excretion of lithium, and did not affect its fractional excretion. The urinary pH of rats with renal ischemia for 90 min was significantly higher than those of the other groups, and the linear regression with the fractional excretion of lithium in rats with renal ischemia showed a moderate correlation (r = 0.650, p = 0.00193). This study demonstrated the effect of renal ischemia on the renal excretion of lithium in rats. It was suggested that not only glomerular filtration but also the reabsorption of lithium was impaired by renal ischemia.
ISSN:0142-2782
1099-081X
DOI:10.1002/bdd.2163