Diabesity and antidiabetic drugs

The prevalence of “diabesity” – diabetes related to obesity – has increased tremendously over the past few decades because of the global obesity epidemic. Although bariatric surgery is the best treatment option for patients with diabesity, a majority of patients are managed only with antidiabetic dr...

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Bibliographic Details
Published in:Molecular aspects of medicine 2019-04, Vol.66, p.3-12
Main Authors: Pappachan, Joseph M., Fernandez, Cornelius J., Chacko, Elias C.
Format: Article
Language:English
Subjects:
Antidiabetic drug combination
Antidiabetic drugs
Contents
Diabesity
Medical management of diabesity
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Summary:The prevalence of “diabesity” – diabetes related to obesity – has increased tremendously over the past few decades because of the global obesity epidemic. Although bariatric surgery is the best treatment option for patients with diabesity, a majority of patients are managed only with antidiabetic drugs for various reasons. Diabetes control with antidiabetic agents may affect diabesity outcomes positively or negatively because of their effects on body weight and other metabolic parameters. For this reason, rational use of anti-diabetic medications is imperative to optimise long-term management of diabesity. Understanding the molecular mechanisms of antidiabetic drugs and/or drug combinations on diabesity outcomes are therefore important not only for the basic scientists but also for clinicians. This review explores the molecular signalling cascades of antidiabetic medications in the management of diabesity.
ISSN:0098-2997
1872-9452
DOI:10.1016/j.mam.2018.10.004