Diabesity and antidiabetic drugs

The prevalence of “diabesity” – diabetes related to obesity – has increased tremendously over the past few decades because of the global obesity epidemic. Although bariatric surgery is the best treatment option for patients with diabesity, a majority of patients are managed only with antidiabetic dr...

Full description

Saved in:
Bibliographic Details
Published in:Molecular aspects of medicine 2019-04, Vol.66, p.3-12
Main Authors: Pappachan, Joseph M., Fernandez, Cornelius J., Chacko, Elias C.
Format: Article
Language:English
Subjects:
Antidiabetic drug combination
Antidiabetic drugs
Contents
Diabesity
Medical management of diabesity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c353t-ad4d4f68c43c2771634d83a7a204f5362864d78f3cee6c7223b6ae382f98d9463
cites cdi_FETCH-LOGICAL-c353t-ad4d4f68c43c2771634d83a7a204f5362864d78f3cee6c7223b6ae382f98d9463
container_end_page 12
container_issue
container_start_page 3
container_title Molecular aspects of medicine
container_volume 66
creator Pappachan, Joseph M.
Fernandez, Cornelius J.
Chacko, Elias C.
description The prevalence of “diabesity” – diabetes related to obesity – has increased tremendously over the past few decades because of the global obesity epidemic. Although bariatric surgery is the best treatment option for patients with diabesity, a majority of patients are managed only with antidiabetic drugs for various reasons. Diabetes control with antidiabetic agents may affect diabesity outcomes positively or negatively because of their effects on body weight and other metabolic parameters. For this reason, rational use of anti-diabetic medications is imperative to optimise long-term management of diabesity. Understanding the molecular mechanisms of antidiabetic drugs and/or drug combinations on diabesity outcomes are therefore important not only for the basic scientists but also for clinicians. This review explores the molecular signalling cascades of antidiabetic medications in the management of diabesity.
doi_str_mv 10.1016/j.mam.2018.10.004
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2130058421</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0098299718300840</els_id><sourcerecordid>2130058421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-ad4d4f68c43c2771634d83a7a204f5362864d78f3cee6c7223b6ae382f98d9463</originalsourceid><addsrcrecordid>eNp9kE9LAzEQxYMotlY_gBfp0cuuSSabZPEk9S8UvOg5pMmspHS7NdkV_PZmafXoYXjM482D-RFyyWjJKJM367K1bckp03kvKRVHZMq04kUtKn5MppTWuuB1rSbkLKU1paxSsjolE6BQMw5iSub3wa4whf57brc-Tx_86PTBzX0cPtI5OWnsJuHFQWfk_fHhbfFcLF-fXhZ3y8JBBX1hvfCikdoJcFwpJkF4DVZZTkVTgeRaCq90Aw5ROsU5rKRF0Lypta-FhBm53vfuYvc5YOpNG5LDzcZusRuS4QworbTIOiNsH3WxSyliY3YxtDZ-G0bNCMasTQZjRjCjlcHkm6tD_bBq0f9d_JLIgdt9APOTXwGjSS7g1qEPEV1vfBf-qf8BACNw3w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2130058421</pqid></control><display><type>article</type><title>Diabesity and antidiabetic drugs</title><source>ScienceDirect Freedom Collection</source><creator>Pappachan, Joseph M. ; Fernandez, Cornelius J. ; Chacko, Elias C.</creator><creatorcontrib>Pappachan, Joseph M. ; Fernandez, Cornelius J. ; Chacko, Elias C.</creatorcontrib><description>The prevalence of “diabesity” – diabetes related to obesity – has increased tremendously over the past few decades because of the global obesity epidemic. Although bariatric surgery is the best treatment option for patients with diabesity, a majority of patients are managed only with antidiabetic drugs for various reasons. Diabetes control with antidiabetic agents may affect diabesity outcomes positively or negatively because of their effects on body weight and other metabolic parameters. For this reason, rational use of anti-diabetic medications is imperative to optimise long-term management of diabesity. Understanding the molecular mechanisms of antidiabetic drugs and/or drug combinations on diabesity outcomes are therefore important not only for the basic scientists but also for clinicians. This review explores the molecular signalling cascades of antidiabetic medications in the management of diabesity.</description><identifier>ISSN: 0098-2997</identifier><identifier>EISSN: 1872-9452</identifier><identifier>DOI: 10.1016/j.mam.2018.10.004</identifier><identifier>PMID: 30391234</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Antidiabetic drug combination ; Antidiabetic drugs ; Contents ; Diabesity ; Medical management of diabesity</subject><ispartof>Molecular aspects of medicine, 2019-04, Vol.66, p.3-12</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-ad4d4f68c43c2771634d83a7a204f5362864d78f3cee6c7223b6ae382f98d9463</citedby><cites>FETCH-LOGICAL-c353t-ad4d4f68c43c2771634d83a7a204f5362864d78f3cee6c7223b6ae382f98d9463</cites><orcidid>0000-0003-0886-5255</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30391234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pappachan, Joseph M.</creatorcontrib><creatorcontrib>Fernandez, Cornelius J.</creatorcontrib><creatorcontrib>Chacko, Elias C.</creatorcontrib><title>Diabesity and antidiabetic drugs</title><title>Molecular aspects of medicine</title><addtitle>Mol Aspects Med</addtitle><description>The prevalence of “diabesity” – diabetes related to obesity – has increased tremendously over the past few decades because of the global obesity epidemic. Although bariatric surgery is the best treatment option for patients with diabesity, a majority of patients are managed only with antidiabetic drugs for various reasons. Diabetes control with antidiabetic agents may affect diabesity outcomes positively or negatively because of their effects on body weight and other metabolic parameters. For this reason, rational use of anti-diabetic medications is imperative to optimise long-term management of diabesity. Understanding the molecular mechanisms of antidiabetic drugs and/or drug combinations on diabesity outcomes are therefore important not only for the basic scientists but also for clinicians. This review explores the molecular signalling cascades of antidiabetic medications in the management of diabesity.</description><subject>Antidiabetic drug combination</subject><subject>Antidiabetic drugs</subject><subject>Contents</subject><subject>Diabesity</subject><subject>Medical management of diabesity</subject><issn>0098-2997</issn><issn>1872-9452</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LAzEQxYMotlY_gBfp0cuuSSabZPEk9S8UvOg5pMmspHS7NdkV_PZmafXoYXjM482D-RFyyWjJKJM367K1bckp03kvKRVHZMq04kUtKn5MppTWuuB1rSbkLKU1paxSsjolE6BQMw5iSub3wa4whf57brc-Tx_86PTBzX0cPtI5OWnsJuHFQWfk_fHhbfFcLF-fXhZ3y8JBBX1hvfCikdoJcFwpJkF4DVZZTkVTgeRaCq90Aw5ROsU5rKRF0Lypta-FhBm53vfuYvc5YOpNG5LDzcZusRuS4QworbTIOiNsH3WxSyliY3YxtDZ-G0bNCMasTQZjRjCjlcHkm6tD_bBq0f9d_JLIgdt9APOTXwGjSS7g1qEPEV1vfBf-qf8BACNw3w</recordid><startdate>201904</startdate><enddate>201904</enddate><creator>Pappachan, Joseph M.</creator><creator>Fernandez, Cornelius J.</creator><creator>Chacko, Elias C.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0886-5255</orcidid></search><sort><creationdate>201904</creationdate><title>Diabesity and antidiabetic drugs</title><author>Pappachan, Joseph M. ; Fernandez, Cornelius J. ; Chacko, Elias C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-ad4d4f68c43c2771634d83a7a204f5362864d78f3cee6c7223b6ae382f98d9463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antidiabetic drug combination</topic><topic>Antidiabetic drugs</topic><topic>Contents</topic><topic>Diabesity</topic><topic>Medical management of diabesity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pappachan, Joseph M.</creatorcontrib><creatorcontrib>Fernandez, Cornelius J.</creatorcontrib><creatorcontrib>Chacko, Elias C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular aspects of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pappachan, Joseph M.</au><au>Fernandez, Cornelius J.</au><au>Chacko, Elias C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabesity and antidiabetic drugs</atitle><jtitle>Molecular aspects of medicine</jtitle><addtitle>Mol Aspects Med</addtitle><date>2019-04</date><risdate>2019</risdate><volume>66</volume><spage>3</spage><epage>12</epage><pages>3-12</pages><issn>0098-2997</issn><eissn>1872-9452</eissn><abstract>The prevalence of “diabesity” – diabetes related to obesity – has increased tremendously over the past few decades because of the global obesity epidemic. Although bariatric surgery is the best treatment option for patients with diabesity, a majority of patients are managed only with antidiabetic drugs for various reasons. Diabetes control with antidiabetic agents may affect diabesity outcomes positively or negatively because of their effects on body weight and other metabolic parameters. For this reason, rational use of anti-diabetic medications is imperative to optimise long-term management of diabesity. Understanding the molecular mechanisms of antidiabetic drugs and/or drug combinations on diabesity outcomes are therefore important not only for the basic scientists but also for clinicians. This review explores the molecular signalling cascades of antidiabetic medications in the management of diabesity.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>30391234</pmid><doi>10.1016/j.mam.2018.10.004</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0886-5255</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0098-2997
ispartof Molecular aspects of medicine, 2019-04, Vol.66, p.3-12
issn 0098-2997
1872-9452
language eng
recordid cdi_proquest_miscellaneous_2130058421
source ScienceDirect Freedom Collection
subjects Antidiabetic drug combination
Antidiabetic drugs
Contents
Diabesity
Medical management of diabesity
title Diabesity and antidiabetic drugs
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T22%3A03%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diabesity%20and%20antidiabetic%20drugs&rft.jtitle=Molecular%20aspects%20of%20medicine&rft.au=Pappachan,%20Joseph%20M.&rft.date=2019-04&rft.volume=66&rft.spage=3&rft.epage=12&rft.pages=3-12&rft.issn=0098-2997&rft.eissn=1872-9452&rft_id=info:doi/10.1016/j.mam.2018.10.004&rft_dat=%3Cproquest_cross%3E2130058421%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c353t-ad4d4f68c43c2771634d83a7a204f5362864d78f3cee6c7223b6ae382f98d9463%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2130058421&rft_id=info:pmid/30391234&rfr_iscdi=true