Effect of preoperative biliary drainage on cholestasis‐associated inflammatory and fibrotic gene signatures in perihilar cholangiocarcinoma

Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently available to guid...

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Bibliographic Details
Published in:British journal of surgery 2019-01, Vol.106 (1), p.55-58
Main Authors: Reiniers, M. J., de Haan, L., Weijer, R., Wiggers, J. K., Jongejan, A., Moerland, P. D., Alles, L. K., van Kampen, A. H. C., van Gulik, T. M., Heger, M., van Golen, R. F.
Format: Article
Language:English
Subjects:
Gallbladder diseases
Gene expression
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Summary:Preoperative biliary drainage (PBD) is used routinely in the evaluation of patients with potentially resectable perihilar cholangiocarcinoma to relieve cholestasis and improve the liver's resilience to surgery. Little preclinical or translatational data are, however, currently available to guide the use of PBD in this patient group. The effect of PBD on hepatic gene expression profiles was therefore studied by microarray analysis. Drainage affects inflammatory and fibrotic gene signatures
ISSN:0007-1323
1365-2168
DOI:10.1002/bjs.11022