ZnCl2-Catalyzed [3 + 2] Cycloaddition of Benzimidates and 2 H-Azirines for the Synthesis of Imidazoles

ZnCl2-catalyzed [3 + 2] cycloaddition reaction of benzimidates and 2 H-azirines has been developed. This convenient method allowed the efficient construction of a series of multisubstituted imidazoles in moderate to good yields under mild reaction conditions. This transformation exhibits good reacti...

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Bibliographic Details
Published in:Journal of organic chemistry 2018-12, Vol.83 (23), p.14791-14796
Main Authors: Shi, Shoujie, Xu, Kang, Jiang, Cheng, Ding, Zhenhua
Format: Article
Language:English
Online Access:Get full text
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Summary:ZnCl2-catalyzed [3 + 2] cycloaddition reaction of benzimidates and 2 H-azirines has been developed. This convenient method allowed the efficient construction of a series of multisubstituted imidazoles in moderate to good yields under mild reaction conditions. This transformation exhibits good reactivity and high functional group tolerance.
ISSN:1520-6904
DOI:10.1021/acs.joc.8b02437