A Dual‐Targeted Organic Photothermal Agent for Enhanced Photothermal Therapy

The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual‐targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondri...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2019-01, Vol.58 (4), p.1057-1061
Main Authors: Wang, Hongyu, Chang, Jinjie, Shi, Mingwan, Pan, Wei, Li, Na, Tang, Bo
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic drugs
Antitumor agents
Biocompatibility
Cancer
cancer treatment
Cytotoxicity
drug delivery
Drug development
Mitochondria
organic photothermal agents
Photothermal conversion
photothermal therapy
Therapy
Tissues
Toxicity
Tumors
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Summary:The development of highly effective anticancer drugs that cause minimal damage to the surrounding normal tissues is a challenging topic in cancer therapy. Herein, we demonstrate a dual‐targeted organic molecule that functions as a photothermal agent by actively targeting tumor tissue and mitochondria to selectively kill cancer cells. The synthesized photothermal agent exhibited high photothermal conversion efficiency, low cytotoxicity, and good biological compatibility. In vivo experiments showed an excellent tumor inhibitory effect of the dual‐targeted photothermal agent. It takes two targets: A small‐molecule organic photothermal agent with two targeting ligands was designed to actively target tumor tissue and mitochondria and thus selectively kill cancer cells. The resulting antitumor agent (see structure) exhibited a high photothermal conversion efficiency of 37.8 %, low cytotoxicity, and good biocompatibility and showed excellent tumor inhibition in vivo.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201811273