Synthesis and characterization of hybrid Anderson hexamolybdoaluminates(III) functionalized with indometacin or cinnamic acid

• Published in: Acta crystallographica. Section C, Crystal structure communications Crystal structure communications, 2018-11, Vol.74 (11), p.1378-1383
• Main Authors: Gumerova, Nadiia I., Blazevic, Amir, Caldera Fraile, Tania, Roller, Alexander, Giester, Gerald, Rompel, Annette
• Format: Article
• Language: English
• Subjects: alkoxylation; antibacterial activity; Cinnamic acid; Crystal structure; hexamolybdoaluminate; indometacin; Infrared radiation; NMR; Nuclear magnetic resonance; organic–inorganic hybrids; polyoxomolybdate; post‐functionalization; Synthesis; X ray spectra; X-ray diffraction
• ISSN: 2053-2296; 0108-2701; 2053-2296; 1600-5759
• DOI: 10.1107/S2053229618012536

The single‐side Al‐centred tris‐functionalized hybrid organic–inorganic Anderson polyoxomolybdates (C16H36N)3[Al(OH)3Mo6O18(OCH2)3CNH(C10H8O)]·C9H7N·4CH3OH·5H2O (AlMo6‐NH‐Cin; Cin is cinnamic acid, C10H9O2) and (C16H36N)3[Al(OH)3Mo6O18(OCH2)3CNH(C19H15ClNO3)]·9H2O (AlMo6‐NH‐Indo; Indo is indometacin, C19H16ClNO4) have been prepared in a mild three‐step synthesis and structurally characterized by single‐crystal X‐ray diffraction, 1H NMR and IR spectroscopies and elemental analysis. Both AlMo6‐NH‐Cin and AlMo6‐NH‐Indo crystallize in the orthorhombic space group Pbca. The antibacterial activities of AlMo6‐NH‐Cin and AlMo6‐NH‐Indo against the Gram‐negative human mucosal pathogen Moraxella catarrhalis were investigated by determination of the minimum inhibitory concentration, which is 32 µg ml−1 for AlMo6‐NH‐Cin and 256 µg ml−1 for AlMo6‐NH‐Indo. A post‐functionalization protocol was used for the synthesis of two new tris‐hybrid Al‐centred Anderson‐type polyoxomolybdates with indometacin or cinnamic acid.