Salvage Carbon-ion Radiotherapy for Isolated Lymph Node Recurrence Following Curative Resection of Esophageal Cancer

Evaluation of the therapeutic efficacy of carbon-ion radiation therapy for isolated lymph node recurrence following curative resection of esophageal cancer. Ten cases with lymph node recurrence after esophageal cancer surgery were treated with carbon-ion radiation therapy. A total of 48.0 Gy [relati...

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Bibliographic Details
Published in:Anticancer research 2018-11, Vol.38 (11), p.6453-6458
Main Authors: Isozaki, Yuka, Yasuda, Shigeo, Akutsu, Yasunori, Shimada, Hideaki, Okazumi, Shinichi, Nabeya, Yoshihiro, Hoshino, Isamu, Murakami, Kentaro, Ebner, Daniel K, Tsuji, Hiroshi, Kamada, Tadashi, Yamada, Shigeru, Matsubara, Hisahiro
Format: Article
Language:English
Subjects:
Biological effects
Cancer
Cancer therapies
Carbon
Esophageal cancer
Esophagus
Lymph nodes
Lymphatic system
Radiation
Radiation therapy
Salvage
Surgery
Survival
Toxicity
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Summary:Evaluation of the therapeutic efficacy of carbon-ion radiation therapy for isolated lymph node recurrence following curative resection of esophageal cancer. Ten cases with lymph node recurrence after esophageal cancer surgery were treated with carbon-ion radiation therapy. A total of 48.0 Gy [relative biologic effectiveness (RBE)] was delivered over 3 weeks with a daily dose of 4.0 Gy (RBE). The median follow-up duration was 27.1 months (range=3-92.0 months) after carbon-ion radiation therapy. The local control rates at 2, 3 and 5 years were 92.4%. The overall survival rates at 2, 3 and 5 years were 70.0%, 58.3% and 21.9%. The median survival period was 45.3 months after carbon-ion radiation therapy. There were no toxicities of grade 3 or higher. Carbon-ion radiation therapy may be a safe and effective treatment option for isolated lymph node recurrence after radical surgery for esophageal cancer.
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.13007