Using CT texture analysis to differentiate between nasopharyngeal carcinoma and age-matched adenoid controls

To investigate the use of texture analysis to quantitatively distinguish nasopharyngeal carcinoma (NPC) from normal adenoid on CT. In this IRB-approved, retrospective study, nasopharyngeal tissues in 13 patients with NPC and 13 control patients were manually contoured, segmented, and imported to an...

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Bibliographic Details
Published in:European journal of radiology 2018-11, Vol.108, p.208-214
Main Authors: Tsai, Amy, Buch, Karen, Fujita, Akifumi, Qureshi, Muhammad Mustafa, Kuno, Hirofumi, Chapman, Margaret N., Li, Baojun, Oda, Masafumi, Truong, Minh Tam, Sakai, Osamu
Format: Article
Language:English
Subjects:
Adenoid
Adenoids - diagnostic imaging
Adult
Aged
Contrast Media
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Nasopharyngeal carcinoma
Nasopharyngeal Carcinoma - diagnostic imaging
Nasopharynx - diagnostic imaging
Radiographic Image Enhancement
Retrospective Studies
Texture analysis
Tomography, X-Ray Computed - methods
Young Adult
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Summary:To investigate the use of texture analysis to quantitatively distinguish nasopharyngeal carcinoma (NPC) from normal adenoid on CT. In this IRB-approved, retrospective study, nasopharyngeal tissues in 13 patients with NPC and 13 control patients were manually contoured, segmented, and imported to an in-house developed texture analysis program, which extracted 41 texture features. Basic descriptive statistics were performed to evaluate for differences in texture parameters between NPC and controls. Statistically significant differences between NPC and controls were seen in 32 of 41 texture features. These significant differences were present in 11 of 12 histogram features, 4 of 5 gray-level co-occurrence matrix features, 7 of 11 gray-level run length features, 4 of 4 gray-level gradient matrix features, and 6 of 9 Laws features. Significant differences in many texture features were seen between NPC and normal adenoids. CT texture analysis may aid in differentiating NPC from normal adenoid tissue.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2018.09.012