Combined treatment with Cinnamaldehyde and β-TCP had an additive effect on bone formation and angiogenesis in critical size calvarial defect in ovariectomized rats

•Cinnamaldehyde plus β-TCP enhances bone formation in osteoporotic bone defect.•Cinnamaldehyde plus β-TCP enhances angiogenesis in osteoporotic bone defect.•Combined treatment shows additive effect on repairment of osteoporotic bone defect.•Cinnamaldehyde plus β-TCP is a potential treatment for oste...

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Published in:Biomedicine & pharmacotherapy 2019-01, Vol.109, p.573-581
Main Authors: Weng, She-Ji, Yan, De-Yi, Tang, Jia-Hao, Shen, Zi-Jian, Wu, Zong-Yi, Xie, Zhong-Jie, Yang, Jia-Yi, Bai, Bing-Li, Chen, Liang, Boodhun, Viraj, Yang, Lin, Da (Eric) Dong, Xiang, Yang, Lei
Format: Article
Language:English
Subjects:
Angiogenesis
Cinnamaldehyde
Osteogenesis
Osteoporosis
β-TCP
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Summary:•Cinnamaldehyde plus β-TCP enhances bone formation in osteoporotic bone defect.•Cinnamaldehyde plus β-TCP enhances angiogenesis in osteoporotic bone defect.•Combined treatment shows additive effect on repairment of osteoporotic bone defect.•Cinnamaldehyde plus β-TCP is a potential treatment for osteoporotic bone defect. Accumulating evidence suggests that improvements in osteogenesis and angiogenesis play an important role in repairing osteoporotic bone defects. Cinnamomum cassia (C. cassia), a traditional Chinese medicinal herb, is reported to show anabolic effects on osteoblasts. However, whether C. cassia could actually repair bone defects in osteoporotic conditions remains unknown. The purpose of this study was to evaluate the effect of combined treatment with Cinnamaldehyde (main oil isolated from the C. cassia) and β-tricalcium phosphate (β-TCP) on bone formation and angiogenesis in critical size calvarial defects in ovariectomized (OVX) rats. Using a previously established OVX model, 5 mm critical size calvarial defect was established in OVX rats. All OVX rats were then randomly divided into OVX group (OVX rats + empty defect), TCP group (OVX rats + β-TCP), and CTCP group (Cinnamaldehyde 75 mg/kg/day for 12 weeks + β-TCP). Twelve weeks after treatment, according to Micro-CT and HE staining, combination of Cinnamaldehyde and β-TCP had an additive effect on bone regeneration compared with other groups (p 
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2018.10.085