Polyethylene glycol/microfibrillar collagen composite as a new resorbable hemostatic bone wax

• Published in: Journal of biomedical materials research 1998-03, Vol.39 (3), p.358-363
• Main Authors: Orgill, Dennis P., Ehret, Frederick W., Regan, John F., Glowacki, Julie, Mulliken, John B.
• Format: Article
• Language: English
• Subjects: Animals; Biocompatibility; Biocompatible Materials - adverse effects; Biocompatible Materials - analysis; Biocompatible Materials - metabolism; Biodegradation; Biological and medical sciences; Bone; Bone and Bones - anatomy & histology; Bone and Bones - physiology; Bone Development - physiology; Bone Substitutes - adverse effects; Bone Substitutes - analysis; Bone Substitutes - metabolism; bone wax; Chemical Phenomena; Chemistry, Physical; Collagen; Collagen - adverse effects; Collagen - chemistry; Fracture Healing - physiology; Growth kinetics; hemostasis; Hemostatics - adverse effects; Hemostatics - analysis; Hemostatics - metabolism; Medical sciences; microcrystalline collagen; microfibrillar collagen; polyethylene glycol; Polyethylene glycols; Polyethylene Glycols - adverse effects; Polyethylene Glycols - chemistry; Rabbits; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Technology. Biomaterials. Equipments. Material. Instrumentation; Viscosity
• ISSN: 0021-9304; 1097-4636
• DOI: 10.1002/(SICI)1097-4636(19980305)39:3<358::AID-JBM3>3.0.CO;2-I

Although bone wax is effective at achieving hemostasis, it is nonresorbable, causes a foreign body reaction, and inhibits osteogenesis. We report development of a polyethylene glycol/microfibrillar collagen composite (PEG/MFC) that has inherent hemostatic qualities, is biodegradable, and is compatible with bone repair. PEG/MFC composite (n = 42) was placed in 5 mm cranial defects in New Zealand white rabbits. Hemostasis and healing were compared to unfilled defects (n = 32) and defects filled with standard bone wax (n = 10). Both PEG/MFC and bone wax handled well and stopped bleeding. The polyethylene glycol component was resorbed by 8 h, and the microfibrillar collagen was resorbed over 2 months, eliciting only a minor inflammatory response during the first month. Defects filled with the PEG/MFC composite showed similar amounts of bony regeneration as did unfilled control defects. At 4 weeks, healing bone accounted for 43 ± 13% in those treated with PEG/MFC and 47 ± 19% defect area in untreated holes. In contrast, less than 1% of the area was bone in defects filled with bone wax (p < 0.05). PEG/MFC composite provided excellent bony hemostasis and did not inhibit bone growth. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 358–363, 1998.