Symmetrical central tegmental tract (CTT) hyperintense lesions on magnetic resonance imaging in children

The central tegmental tract (CTT) is mainly the extrapyramidal tract connecting between the red nucleus and the inferior olivary nucleus. There are only a few case reports describing CTT abnormalities on magnetic resonance imaging (MRI) in children. Our purpose was to evaluate the frequency of CTT l...

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Bibliographic Details
Published in:European radiology 2009-02, Vol.19 (2), p.462-469
Main Authors: Yoshida, Shoko, Hayakawa, Katsumi, Yamamoto, Akira, Aida, Noriko, Okano, Souzo, Matsushita, Hiroko, Kanda, Toyoko, Yamori, Yuriko, Yoshida, Naoko, Hirota, Haruyo
Format: Article
Language:English
Subjects:
Brain - abnormalities
Brain - pathology
Brain Injuries - diagnosis
Brain Injuries - pathology
Case reports
Case-Control Studies
Cerebral palsy
Cerebral Palsy - diagnosis
Cerebral Palsy - pathology
Child
Child development
Child, Preschool
Children with disabilities
Congenital diseases
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging - methods
Disease
Female
Gallbladder diseases
Hospitals
Humans
Hypoxia
Image Processing, Computer-Assisted
Imaging
Infant
Internal Medicine
Interventional Radiology
Ischemia
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Metabolic disorders
Neuroradiology
Pediatric
Pediatrics
Prevalence
Radiology
Retrospective Studies
Tumors
Ultrasound
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Summary:The central tegmental tract (CTT) is mainly the extrapyramidal tract connecting between the red nucleus and the inferior olivary nucleus. There are only a few case reports describing CTT abnormalities on magnetic resonance imaging (MRI) in children. Our purpose was to evaluate the frequency of CTT lesions and their characteristics on MRI, and to correlate the MR imaging findings with clinical features. We reviewed retrospectively the MR images of 392 children (215 boys and 177 girls) ranging in age from 1 to 6 years. To evaluate symmetrical CTT hyperintense lesions, we defined a CTT lesion as an area of bilateral symmetrical hyperintensity in the tegmentum pontis on both T2-weighted images and diffusion-weighted images in more than two slices. We measured the ADC (apparent diffusion coefficient) values of symmetrical CTT hyperintensity, and compared them with those of children without CTT abnormality. CTT lesions were detected in 20 (5.1%) of the 392 children. The mean ADC value for these 20 children was significantly lower than that of the normal CTT ( p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-008-1167-7