Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes

The disorders of the central nervous system associated with cancer by remote immune-mediated mechanisms are a heterogeneous group. These disorders encompass the classic paraneoplastic disorders and the recently recognized autoimmune encephalitis associated with antibodies against neuronal cell surfa...

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Bibliographic Details
Published in:Current oncology reports 2018-11, Vol.20 (11), p.92-11, Article 92
Main Authors: Grativvol, Ronnyson Susano, Cavalcante, Wagner Cid Palmeira, Castro, Luiz Henrique Martins, Nitrini, Ricardo, Simabukuro, Mateus Mistieri
Format: Article
Language:English
Subjects:
Acids
Antibodies
Antigens
Autoimmune diseases
Cancer
Cell surface
Central nervous system
Disease
Encephalitis
Encephalomyelitis
Etiology
Glioma
Malignancy
Medical diagnosis
Medicine
Medicine & Public Health
Metastasis
Nervous system
Neuro-oncology (S Nagpal
Neurodegeneration
Neurological disorders
Neuromuscular diseases
Oncology
Patients
Proteins
Section Editor
Topical Collection on Neuro-oncology
Tumors
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Summary:The disorders of the central nervous system associated with cancer by remote immune-mediated mechanisms are a heterogeneous group. These disorders encompass the classic paraneoplastic disorders and the recently recognized autoimmune encephalitis associated with antibodies against neuronal cell surface or synaptic proteins that occur with or without cancer association. In the last decade, the new surge of interest in neuronal diseases associated with anti-neuronal antibodies led to the rapid discovery of new forms of disease that have different manifestations and were not previously suspected to be immune mediated. The recognition of these syndromes is important because it may lead to early detection of an underlying malignancy and prompt initiation of treatment, improving chances for a better outcome.
ISSN:1523-3790
1534-6269
DOI:10.1007/s11912-018-0721-y