Surfactant‐assisted‐water‐exposed versus surfactant‐aqueous‐solution‐exposed electrospinning of novel super hydrophilic polycaprolactone based fibers: Analysis of drug release behavior

• Published in: Journal of biomedical materials research. Part A 2019-03, Vol.107 (3), p.597-609
• Main Authors: Zargarian, Seyed Shahrooz, Haddadi‐Asl, Vahid, Kafrashian, Zahra, Azarnia, Mojdeh, Mirhosseini, Mohammad Masoud, Seyedjafari, Ehsan
• Format: Article
• Language: English
• Subjects: Aqueous solutions; blend electrospinning; Chloroform; Delayed-Action Preparations - chemical synthesis; Delayed-Action Preparations - chemistry; drug delivery; Drug delivery systems; Electrospinning; Enrichment; Exposure; Fibers; Hydrophilicity; Hydrophobicity; Mats; Mechanical properties; Migration; Miscibility; Myelin; Nanofibers - chemistry; Pluronic; Poloxalene - chemistry; Polycaprolactone; Polyesters - chemistry; Polymers; pulsatile release; Scaffolds; Surface-Active Agents - chemistry; Surfactants; Water - chemistry; Weight
• ISSN: 1549-3296; 1552-4965
• DOI: 10.1002/jbm.a.36575

Surface hydrophilicity and scaffold integrity determine the drug release behavior of drug loaded electrospun fibrous mats. When mixture miscibility is acceptable, blend electrospinning of hydrophobic with hydrophilic polymers can improve scaffold hydrophilicity while the hydrophobic polymer maintains the mechanical strength of scaffold. Polycaprolactone (PCL) and Pluronic P123 (P123) blend electrospinning has been investigated. In routine blend electrospinning, surface enrichment of Pluronic sets a limit for P123 weight ratio in which exceeding from that limit causes the excess P123 to be accumulated within the electrospun fiber core. To overcome this setback, a method named surfactant assisted water exposed (SAWE) electrospinning was introduced which was proven to be effective for increasing the surface enrichment of Pluronic. In order to test the validity of this method, the electrospinning of solution containing PCL which is exposed to aqueous solution of P123 was investigated. This new method was named surfactant aqueous solution exposed (SASE) electrospinning. Myelin formation at the contact interface of aqueous solution and chloroform solution was studied and it was found that this layer can effectively barricade the migration of Pluronic chains between immiscible phases. For SASE, fiber surface coverage by P123 was uneven and loose. Electrospun scaffolds from SAWE and SASE were loaded with drug to investigate the effect of the exposure time during electrospinning on in vitro drug release. By increasing the exposure time, the abnormal two‐stage phased release profile of SAWE became normal with moderate initial burst. Longer exposure time increased the initial burst of the drug loaded SASE fibers. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 597–609, 2019.