Impaired microvascular reactivity in gestational diabetes is associated with altered glycemic parameters

Objectives To assess microvascular reactivity and glycemic parameters in GDM compared to age and GA matched controls. Methods This study involved 21 GDM patients and 31 controls. Microvascular reactivity was assessed using LDF and PORH. Microvascular parameters; PORHmax, PORHpeak, and time to peak p...

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Published in:Microcirculation (New York, N.Y. 1994) N.Y. 1994), 2019-01, Vol.26 (1), p.e12513-n/a
Main Authors: Rahman, Aisyah, Munisamy, Seetha, Ghaffar, Nor Aliza, Mahmood, Nik Zaki, Rasool, Aida H. G.
Format: Article
Language:English
Subjects:
Diabetes
gestational diabetes
Insulin resistance
laser Doppler fluximetry
microvascular reactivity
post‐occlusive skin reactive hyperemia
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cited_by cdi_FETCH-LOGICAL-c3573-9aaf39765e23d35142546765c3feedba30c2a94eb1d64d4ec1be356e86f3a90f3
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container_title Microcirculation (New York, N.Y. 1994)
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creator Rahman, Aisyah
Munisamy, Seetha
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Mahmood, Nik Zaki
Rasool, Aida H. G.
description Objectives To assess microvascular reactivity and glycemic parameters in GDM compared to age and GA matched controls. Methods This study involved 21 GDM patients and 31 controls. Microvascular reactivity was assessed using LDF and PORH. Microvascular parameters; PORHmax, PORHpeak, and time to peak perfusion (Tp) were recorded after the release of 3 minutes’ upper arm occlusion. HOMA‐IR was performed to evaluate insulin resistance. Results Average age and GA for subjects were 32.9 years and 29.2 weeks. Mean FBG and a 2‐hour postprandial for GDM and controls were 4.87 ± 0.71 vs 3.99 ± 0.59 mmol/L; P 
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G.</creator><creatorcontrib>Rahman, Aisyah ; Munisamy, Seetha ; Ghaffar, Nor Aliza ; Mahmood, Nik Zaki ; Rasool, Aida H. G.</creatorcontrib><description>Objectives To assess microvascular reactivity and glycemic parameters in GDM compared to age and GA matched controls. Methods This study involved 21 GDM patients and 31 controls. Microvascular reactivity was assessed using LDF and PORH. Microvascular parameters; PORHmax, PORHpeak, and time to peak perfusion (Tp) were recorded after the release of 3 minutes’ upper arm occlusion. HOMA‐IR was performed to evaluate insulin resistance. Results Average age and GA for subjects were 32.9 years and 29.2 weeks. Mean FBG and a 2‐hour postprandial for GDM and controls were 4.87 ± 0.71 vs 3.99 ± 0.59 mmol/L; P &lt; 0.001 and 9.50 ± 1.8 vs 5.67 ± 1.0 mmol/L; P &lt; 0.001. Fasting insulin (13.88 ± 18.9 vs 8.37 ± 11.0 μLU/mL; P = 0.031) and HOMA‐IR (3.14 ± 4.6 vs 1.52 ± 2.2; P = 0.004) were higher in GDM. Tp was prolonged in GDM (16.27 ± 4.3 vs 13.86 ± 2.1 seconds; P = 0.011). Positive correlations were seen between Tp and FBG and 2‐hour postprandial levels. Conclusion Tp was prolonged in GDM compared to age‐matched controls, indicating impaired microvascular reactivity.</description><identifier>ISSN: 1073-9688</identifier><identifier>EISSN: 1549-8719</identifier><identifier>DOI: 10.1111/micc.12513</identifier><identifier>PMID: 30422359</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Diabetes ; gestational diabetes ; Insulin resistance ; laser Doppler fluximetry ; microvascular reactivity ; post‐occlusive skin reactive hyperemia</subject><ispartof>Microcirculation (New York, N.Y. 1994), 2019-01, Vol.26 (1), p.e12513-n/a</ispartof><rights>2018 John Wiley &amp; Sons Ltd</rights><rights>2018 John Wiley &amp; Sons Ltd.</rights><rights>Copyright © 2019 John Wiley &amp; Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3573-9aaf39765e23d35142546765c3feedba30c2a94eb1d64d4ec1be356e86f3a90f3</citedby><cites>FETCH-LOGICAL-c3573-9aaf39765e23d35142546765c3feedba30c2a94eb1d64d4ec1be356e86f3a90f3</cites><orcidid>0000-0001-7893-2391</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30422359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rahman, Aisyah</creatorcontrib><creatorcontrib>Munisamy, Seetha</creatorcontrib><creatorcontrib>Ghaffar, Nor Aliza</creatorcontrib><creatorcontrib>Mahmood, Nik Zaki</creatorcontrib><creatorcontrib>Rasool, Aida H. G.</creatorcontrib><title>Impaired microvascular reactivity in gestational diabetes is associated with altered glycemic parameters</title><title>Microcirculation (New York, N.Y. 1994)</title><addtitle>Microcirculation</addtitle><description>Objectives To assess microvascular reactivity and glycemic parameters in GDM compared to age and GA matched controls. Methods This study involved 21 GDM patients and 31 controls. Microvascular reactivity was assessed using LDF and PORH. Microvascular parameters; PORHmax, PORHpeak, and time to peak perfusion (Tp) were recorded after the release of 3 minutes’ upper arm occlusion. HOMA‐IR was performed to evaluate insulin resistance. Results Average age and GA for subjects were 32.9 years and 29.2 weeks. Mean FBG and a 2‐hour postprandial for GDM and controls were 4.87 ± 0.71 vs 3.99 ± 0.59 mmol/L; P &lt; 0.001 and 9.50 ± 1.8 vs 5.67 ± 1.0 mmol/L; P &lt; 0.001. Fasting insulin (13.88 ± 18.9 vs 8.37 ± 11.0 μLU/mL; P = 0.031) and HOMA‐IR (3.14 ± 4.6 vs 1.52 ± 2.2; P = 0.004) were higher in GDM. Tp was prolonged in GDM (16.27 ± 4.3 vs 13.86 ± 2.1 seconds; P = 0.011). Positive correlations were seen between Tp and FBG and 2‐hour postprandial levels. Conclusion Tp was prolonged in GDM compared to age‐matched controls, indicating impaired microvascular reactivity.</description><subject>Diabetes</subject><subject>gestational diabetes</subject><subject>Insulin resistance</subject><subject>laser Doppler fluximetry</subject><subject>microvascular reactivity</subject><subject>post‐occlusive skin reactive hyperemia</subject><issn>1073-9688</issn><issn>1549-8719</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LwzAYgIMoTqcXf4AEvIiwmY9-5SjDj8HEi57L2_TtltGuNWk39u9N7fTgwVySwJOHNw8hV5xNuV_3ldF6ykXI5RE542GgJknM1bE_s1hOVJQkI3Lu3JoxliRCnZKRZIEQMlRnZDWvGjAWc-ottt6C010JlloE3ZqtaffUbOgSXQutqTdQ0txAhi06ahwF52ptoPXPd6ZdUShb7F3Lcq_RC2kDFipPW3dBTgooHV4e9jH5eHp8n71MFm_P89nDYqJl2E8LUEgVRyEKmcuQByIMIn_VskDMM5BMC1ABZjyPgjxAzTOUYYRJVEhQrJBjcjt4G1t_dn7utDJOY1nCBuvOpYJLEUseMO7Rmz_ouu6s_2NPRTGPlPKVxuRuoHwe5ywWaWNNBXafcpb2_dO-f_rd38PXB2WXVZj_oj_BPcAHYGdK3P-jSl_ns9kg_QJzs5Fp</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Rahman, Aisyah</creator><creator>Munisamy, Seetha</creator><creator>Ghaffar, Nor Aliza</creator><creator>Mahmood, Nik Zaki</creator><creator>Rasool, Aida H. G.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7893-2391</orcidid></search><sort><creationdate>201901</creationdate><title>Impaired microvascular reactivity in gestational diabetes is associated with altered glycemic parameters</title><author>Rahman, Aisyah ; Munisamy, Seetha ; Ghaffar, Nor Aliza ; Mahmood, Nik Zaki ; Rasool, Aida H. G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3573-9aaf39765e23d35142546765c3feedba30c2a94eb1d64d4ec1be356e86f3a90f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Diabetes</topic><topic>gestational diabetes</topic><topic>Insulin resistance</topic><topic>laser Doppler fluximetry</topic><topic>microvascular reactivity</topic><topic>post‐occlusive skin reactive hyperemia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rahman, Aisyah</creatorcontrib><creatorcontrib>Munisamy, Seetha</creatorcontrib><creatorcontrib>Ghaffar, Nor Aliza</creatorcontrib><creatorcontrib>Mahmood, Nik Zaki</creatorcontrib><creatorcontrib>Rasool, Aida H. G.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahman, Aisyah</au><au>Munisamy, Seetha</au><au>Ghaffar, Nor Aliza</au><au>Mahmood, Nik Zaki</au><au>Rasool, Aida H. G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired microvascular reactivity in gestational diabetes is associated with altered glycemic parameters</atitle><jtitle>Microcirculation (New York, N.Y. 1994)</jtitle><addtitle>Microcirculation</addtitle><date>2019-01</date><risdate>2019</risdate><volume>26</volume><issue>1</issue><spage>e12513</spage><epage>n/a</epage><pages>e12513-n/a</pages><issn>1073-9688</issn><eissn>1549-8719</eissn><abstract>Objectives To assess microvascular reactivity and glycemic parameters in GDM compared to age and GA matched controls. Methods This study involved 21 GDM patients and 31 controls. Microvascular reactivity was assessed using LDF and PORH. Microvascular parameters; PORHmax, PORHpeak, and time to peak perfusion (Tp) were recorded after the release of 3 minutes’ upper arm occlusion. HOMA‐IR was performed to evaluate insulin resistance. Results Average age and GA for subjects were 32.9 years and 29.2 weeks. Mean FBG and a 2‐hour postprandial for GDM and controls were 4.87 ± 0.71 vs 3.99 ± 0.59 mmol/L; P &lt; 0.001 and 9.50 ± 1.8 vs 5.67 ± 1.0 mmol/L; P &lt; 0.001. Fasting insulin (13.88 ± 18.9 vs 8.37 ± 11.0 μLU/mL; P = 0.031) and HOMA‐IR (3.14 ± 4.6 vs 1.52 ± 2.2; P = 0.004) were higher in GDM. Tp was prolonged in GDM (16.27 ± 4.3 vs 13.86 ± 2.1 seconds; P = 0.011). Positive correlations were seen between Tp and FBG and 2‐hour postprandial levels. Conclusion Tp was prolonged in GDM compared to age‐matched controls, indicating impaired microvascular reactivity.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30422359</pmid><doi>10.1111/micc.12513</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7893-2391</orcidid></addata></record>
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subjects Diabetes
gestational diabetes
Insulin resistance
laser Doppler fluximetry
microvascular reactivity
post‐occlusive skin reactive hyperemia
title Impaired microvascular reactivity in gestational diabetes is associated with altered glycemic parameters
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