Microbiome and its relation to gestational diabetes

Purpose Gestational diabetes mellitus (GDM), the major endocrine pathology in pregnancy, has been associated with the development of an intense inflammatory process and increased insulin resistance. The maternal microbiota is involved in several metabolic functions; however, its role in GDM physiopa...

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Bibliographic Details
Published in:Endocrine 2019-05, Vol.64 (2), p.254-264
Main Authors: Cortez, Ramon V., Taddei, Carla R., Sparvoli, Luiz G., Ângelo, Ana G. S., Padilha, Marina, Mattar, Rosiane, Daher, Silvia
Format: Article
Language:English
Subjects:
Adult
Blood Glucose - metabolism
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes, Gestational - blood
Diabetes, Gestational - microbiology
Dysbacteriosis
Endocrinology
Female
Gastrointestinal Microbiome
Gestation
Humanities and Social Sciences
Humans
Inflammation
Insulin
Insulin Resistance - physiology
Internal Medicine
Intestine
Medicine
Medicine & Public Health
Metabolic disorders
Metabolism
Microbiomes
Microbiota
Mouth - microbiology
multidisciplinary
Next-generation sequencing
Original Article
Pregnancy
Pregnancy Trimester, Third - blood
Science
Vagina
Vagina - microbiology
Young Adult
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Summary:Purpose Gestational diabetes mellitus (GDM), the major endocrine pathology in pregnancy, has been associated with the development of an intense inflammatory process and increased insulin resistance. The maternal microbiota is involved in several metabolic functions; however, its role in GDM physiopathology remains unclear. The aim of this study was to assess the composition of the microbiota at different sites and evaluate its relationship with the occurrence of GDM. Methods This cross-sectional study recruited women in the third trimester of gestation with and without GDM. Oral, vaginal, and stool samples were evaluated using next-generation sequencing. We included 68 participants: 26 with and 42 without GDM. Results The analysis of the oral microbiome did not show significant differences in phyla and genus among the studied groups. In contrast, GDM patients presented a specific vaginal and intestinal microbiome composition, which was less diverse than those found in the control group, showing genera related to dysbiosis. Conclusions Our findings suggest that changes in the composition of the vaginal and intestinal microbiome might be involved in the development of GDM. The follow-up of these patients in order to evaluate vaginal and intestinal samples after delivery may contribute to understanding the development of metabolic disease in women with previous GDM.
ISSN:1355-008X
1559-0100
DOI:10.1007/s12020-018-1813-z