Palladium-Catalyzed Intermolecular Dehydrogenative Carboamination of Alkenes with Amines and N‑Substituted Isatin

The first intermolecular dehydrogenative carboamination of alkenes with aromatic amines and N-substituted isatin has been developed using palladium as a catalyst. This multicomponent reaction is a valuable synthetic tool for difunctionalization of the alkene with retention of the C–C double bond. Th...

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Bibliographic Details
Published in:Organic letters 2018-12, Vol.20 (23), p.7451-7454
Main Authors: Pratap, Kemant, Kumar, Atul
Format: Article
Language:English
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Summary:The first intermolecular dehydrogenative carboamination of alkenes with aromatic amines and N-substituted isatin has been developed using palladium as a catalyst. This multicomponent reaction is a valuable synthetic tool for difunctionalization of the alkene with retention of the C–C double bond. This reaction has two very distinguishing features: (1) the formation of the C–N and C–C bonds with retention of the double bond and (2) high regioselectivity. Thus, this strategy has opened up a new area in chemistry.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b03196