Effects of the aqueous extract of fresh leaves of Calotropis procera on haematological and biochemical parameters in female rabbits

Calotropis procera has been reported to be medicinal and toxic in animals. A toxicological evaluation of the aqueous extract of its fresh leaves was conducted in female rabbits (Oryctolagus cuniculus). Low levels of phytochemicals (alkaloids, saponins, tannins, cardiac glycosides, and flavonoids) we...

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Bibliographic Details
Published in:African journal of biotechnology 2009-10, Vol.8 (19), p.5071-5075
Main Authors: Mbako, J D, Adamu, Z, Afutu, J K, Aliyu, A, David, S, Umar, M B, Nduaka, C
Format: Article
Language:English
Subjects:
Calotropis procera
Oryctolagus cuniculus
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Summary:Calotropis procera has been reported to be medicinal and toxic in animals. A toxicological evaluation of the aqueous extract of its fresh leaves was conducted in female rabbits (Oryctolagus cuniculus). Low levels of phytochemicals (alkaloids, saponins, tannins, cardiac glycosides, and flavonoids) were found while 0.23, 0.03, 0.82 and 9.5 mg/g of iron, lead, sodium and potassium, respectively, were detected. Acute toxicity study was conducted with oral administration of 200, 400, 800 and 1600 mg/kg of the extract once to groups I, II, III and IV, respectively. Four rabbits died within 24 h and LD sub(50) was estimated (940 mg/kg). 80, 40 and 20 mg/kg of the extract were administered daily to groups I, II, and III, respectively, during sub-acute toxicity study for 14 days. All controls were given water. Statistical analysis of aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), albumin and protein showed no significant changes at P
ISSN:1684-5315
1684-5315