Accumulation of trimethylamine and trimethylamine-N-oxide in end-stage renal disease patients undergoing haemodialysis

Background. Trimethylamine (TMA) is a short-chain tertiary aliphatic amine that is derived from the diet either directly from the consumption of foods high in TMA or by the intake of food high in precursors to TMA, such as trimethylamine-N-oxide (TMNO), choline and l-carnitine. The clinical signific...

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Bibliographic Details
Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2006-05, Vol.21 (5), p.1300-1304
Main Authors: Bain, Marcus A., Faull, Randall, Fornasini, Gianfranco, Milne, Robert W., Evans, Allan M.
Format: Article
Language:English
Subjects:
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Biomarkers - blood
Case-Control Studies
Disease Progression
Emergency and intensive care: renal failure. Dialysis management
end-stage renal disease
Female
Follow-Up Studies
gas chromatography
Humans
Intensive care medicine
Kidney Failure, Chronic - blood
Kidney Failure, Chronic - diagnosis
Kidney Failure, Chronic - therapy
Kidney Function Tests
Male
Medical sciences
Methylamines - blood
Methylamines - metabolism
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Probability
Reference Values
Renal Dialysis - adverse effects
Renal Dialysis - methods
Renal failure
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the urinary system
trimethylamine
trimethylamine-N-oxide
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Summary:Background. Trimethylamine (TMA) is a short-chain tertiary aliphatic amine that is derived from the diet either directly from the consumption of foods high in TMA or by the intake of food high in precursors to TMA, such as trimethylamine-N-oxide (TMNO), choline and l-carnitine. The clinical significance of TMA may be related to its potential to contribute to neurological toxicity and ‘uraemic breath’ in patients with end-stage renal disease (ESRD). Methods. Concentrations of TMA and TMNO in plasma from 10 healthy adults (not on haemodialysis) and 10 adults with ESRD undergoing haemodialysis (pre- and post-dialysis) were determined by gas chromatography–mass spectrometry. Results. The concentrations of TMA and TMNO in pre-dialysis plasma (1.39±0.483 and 99.9±31.9 μM, respectively) were significantly (P
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gfk056