Photostability of oxazoline RNA-precursors in UV-rich prebiotic environments

Pentose aminooxazolines and oxazolidinone thiones are considered as the key precursors which could have enabled the formation of RNA nucleotides under the conditions of early Earth. UV-irradiation experiments and quantum-chemical calculations demonstrate that these compounds are remarkably photostab...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-11, Vol.54 (95), p.13407-13410
Main Authors: Janicki, Mikołaj J, Roberts, Samuel J, Šponer, Jiří, Powner, Matthew W, Góra, Robert W, Szabla, Rafał
Format: Article
Language:English
Subjects:
Oxazoles - chemistry
Photochemical Processes
Prebiotics
RNA Precursors - chemistry
Ultraviolet Rays
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Summary:Pentose aminooxazolines and oxazolidinone thiones are considered as the key precursors which could have enabled the formation of RNA nucleotides under the conditions of early Earth. UV-irradiation experiments and quantum-chemical calculations demonstrate that these compounds are remarkably photostable and could accumulate over long periods of time in UV-rich prebiotic environments to undergo stereoisomeric purification.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07343k