Effects of chronic 4-n-nonylphenol treatment on aortic vasoconstriction and vasorelaxation in rats

4-Nonylphenol (para-nonylphenol, 4-NP), metabolites including linear and branched isoforms of nonylphenol (n-NP and t-NP, respectively), has been considered an endocrine disrupting substance resulting in reproductive dysfunction and increasing reactive oxygen species production in testis, liver, kid...

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Bibliographic Details
Published in:Archives of toxicology 2009-10, Vol.83 (10), p.941-946
Main Authors: Hsieh, Chi-Ying, Miaw, Chang-Ling, Hsieh, Chien-Cheng, Tseng, Hui-Ching, Yang, Yuan-Han, Yen, Chia-Hung
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Coronary vessels
Endocrine Disruptors - administration & dosage
Endocrine Disruptors - pharmacology
Environmental Health
Enzymes
Male
Medical sciences
NADP - metabolism
Occupational Medicine/Industrial Medicine
Organ Toxicity and Mechanisms
Oxidation
Pharmacology/Toxicology
Phenols - administration & dosage
Phenols - pharmacology
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species - metabolism
Rodents
Toxicity Tests, Chronic
Toxicology
Vasoconstriction - drug effects
Vasodilation - drug effects
Xanthine Oxidase - metabolism
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Summary:4-Nonylphenol (para-nonylphenol, 4-NP), metabolites including linear and branched isoforms of nonylphenol (n-NP and t-NP, respectively), has been considered an endocrine disrupting substance resulting in reproductive dysfunction and increasing reactive oxygen species production in testis, liver, kidney, and brain. However, to date, whether vasculature is susceptible to NP exposure remains to be unclear. In this study, we have investigated the effects of chronic in vivo 4-n-NP exposure on vasoconstriction and vasorelaxation in male rats. After a 20-week 4-n-NP treatment orally at the dosage of 10 and 50 μM in the drinking water, phenylephrine- and potassium chloride-induced concentration-dependent responsiveness assessed by wire myograph were both significantly higher in aorta isolated from 4-n-NP-treated rats compared with control rats, but acetylcholine-induced vasorelaxation was similar between these two groups. In addition, systemic oxidative stress and vascular, but not intestinal, oxidant enzyme activities assessed by lucigenin-amplified chemiluminescence were all markedly higher in 4-n-NP-treated rats. In conclusion, our results suggested that chronic in vivo 4-n-NP exposure augments vascular contractile responsiveness through enhanced vascular oxidant enzyme activity.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-009-0447-6