The role of calcium-calmodulin-dependent protein kinase II in modulation of spatial memory in morphine sensitized rats

•Morphine-induced spatial memory impairment improved by morphine sensitization.•CamKII inhibition in the hippocampus facilitated memory retention induced by morphine sensitization.•Glutamate NMDA receptor plays a major role in morphine-sensitization memory retrieval. It has been shown that drug addi...

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Bibliographic Details
Published in:Behavioural brain research 2019-02, Vol.359, p.298-303
Main Authors: Sadat-Shirazi, Mitra-Sadat, Ahmadian-Moghadam, Hamid, Khalifeh, Solmaz, Nouri Zadeh-Tehrani, Setareh, Farahmandfar, Maryam, Zarrindast, Mohammad-Reza
Format: Article
Language:English
Subjects:
CAMK II inhibitor
Morphine sensitization
NMDA receptors
Spatial memory
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Summary:•Morphine-induced spatial memory impairment improved by morphine sensitization.•CamKII inhibition in the hippocampus facilitated memory retention induced by morphine sensitization.•Glutamate NMDA receptor plays a major role in morphine-sensitization memory retrieval. It has been shown that drug addiction and memory system are related but the signaling cascades underlying this interaction is not completely revealed yet. It has been demonstrated that binding of Calcium-calmodulin-dependent protein kinase II (CaMKII) to NMDA receptor is important in the memory process. The main objective of the study was to evaluate the role of CaMKII on the spatial memory of rats which previously were sensitized by morphine. The effect of CaMKII inhibitor (KN-93) on memory changes was investigated by hippocampal microinjection of KN-93 on the morphine-sensitized rats. Also, the role of the NMDA receptor in memory retention by KN-93 on the morphine sensitized rat was investigated with NMDA agonist and antagonist. Sensitization was induced by morphine injection (once daily for 3 days) followed by 5 days free of the drug before the trial phase. For the evaluation of spatial memory, the Morris Water Maze test (MWM) was used. Results showed that pre-trial administration of morphine, induced amnesia in MWM (p 
ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2018.11.010