Cyclopalladated compounds as chemotherapeutic agents: Antitumor activity against a murine melanoma cell line

Palladacycle compounds obtained from N, N‐dimethyl‐1‐phenethylamine (dmpa), phenyl‐2‐pyridinyl‐acetylene and 1‐phenyl‐3‐N, N‐dimethylamine‐propine, respectively, were complexed to 1, 2 ethanebis (diphenylphosphine) (dppe) ligand to synthesize antitumor cyclopalladated complexes that were tested in v...

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Bibliographic Details
Published in:International journal of cancer 2003-11, Vol.107 (3), p.498-504
Main Authors: Rodrigues, Elaine G., Silva, Luiz S., Fausto, Daniela M., Hayashi, Marina S., Dreher, Simone, Santos, Edson L., Pesquero, João B., Travassos, Luiz R., Caires, Antonio C.F.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Antineoplastic Agents - pharmacology
antitumor activity
apoptosis
Apoptosis - drug effects
B16F10 murine melanoma
Biological and medical sciences
Chemotherapy
DNA, Neoplasm - metabolism
Male
Medical sciences
Melanoma, Experimental - drug therapy
Melanoma, Experimental - pathology
Mice
Mice, Inbred C57BL
Oxygen Consumption - drug effects
palladacycle‐biphosphinic complexes
palladium
Palladium - pharmacology
Pharmacology. Drug treatments
Tumor Cells, Cultured
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Summary:Palladacycle compounds obtained from N, N‐dimethyl‐1‐phenethylamine (dmpa), phenyl‐2‐pyridinyl‐acetylene and 1‐phenyl‐3‐N, N‐dimethylamine‐propine, respectively, were complexed to 1, 2 ethanebis (diphenylphosphine) (dppe) ligand to synthesize antitumor cyclopalladated complexes that were tested in vitro and in vivo against syngeneic B16F10‐Nex2 murine melanoma cells of low immunogenicity implanted subcutaneously in mice. Complexes were not toxic to mice injected 3 times i.p. with as much as 60 μM/animal/week. Of 3 cyclopalladated complexes that were inhibitory in vitro at low concentrations (
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.11434