Chemerin as a biomarker at the intersection of inflammation, chemotaxis, coagulation, fibrinolysis and metabolism in resectable non-small cell lung cancer

•Circulating chemerin is independently associated with NSCLC risk.•Chemerin correlates with metabolic, tumor, inflammatory and hemostatic parameters.•Hemostatic parameters are independent predictors of circulating chemerin in NSCLC.•Circulating chemerin presents a modest discriminative ability for N...

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Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2018-11, Vol.125, p.291-299
Main Authors: Sotiropoulos, George P., Dalamaga, Maria, Antonakos, Georgios, Marinou, Ioanna, Vogiatzakis, Evaggelos, Kotopouli, Marianna, Karampela, Irene, Christodoulatos, Gerasimos Socrates, Lekka, Antigoni, Papavassiliou, Athanasios G.
Format: Article
Language:English
Subjects:
Adipocytokine
Adiponectin
Aged
Biomarker
Biomarkers, Tumor - metabolism
Blood Coagulation - physiology
Carcinoma, Non-Small-Cell Lung - metabolism
Carcinoma, Non-Small-Cell Lung - pathology
Case-Control Studies
Chemerin
Chemokines - metabolism
Chemotaxis
Chemotaxis - physiology
Coagulation
Female
Fibrinolysis
Fibrinolysis - physiology
Humans
Inflammation - immunology
Insulin resistance
Insulin Resistance - physiology
Intercellular Signaling Peptides and Proteins - metabolism
Leptin
Lung cancer
Lung Neoplasms - metabolism
Lung Neoplasms - pathology
Male
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Summary:•Circulating chemerin is independently associated with NSCLC risk.•Chemerin correlates with metabolic, tumor, inflammatory and hemostatic parameters.•Hemostatic parameters are independent predictors of circulating chemerin in NSCLC.•Circulating chemerin presents a modest discriminative ability for NSCLC diagnosis.•Chemerin is at the intersection of inflammatory, hemostatic and metabolic networks. Chemerin is an emerging adipocytokine at the intersection of inflammation, chemotaxis, thrombosis, fibrinolysis and metabolism. Our aims were 1) to explore circulating chemerin in resectable non-small cell lung cancer (NSCLC) taking into account its several interfaces; 2) to study its diagnostic potential; and 3) to assess its associations with clinicopathological features of NSCLC. In a large case-control study, serum chemerin, insulin resistance and lipid parameters, classic adipocytokines, inflammatory, coagulation, fibrinolysis and tumor biomarkers were determined in 110 consecutive patients with resectable NSCLC and 110 healthy controls matched on age (± 5 years), gender and date of blood draw (± 1 month). NSCLC cases exhibited significantly elevated circulating chemerin compared to controls (p 
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2018.10.010