Social cognitive group treatment for impaired insight in psychosis: A multicenter randomized controlled trial

The majority of people with schizophrenia has impaired insight, which is related to a poorer outcome. In this study, we evaluate a new psychosocial intervention ‘REFLEX’ aimed at improving insight in people with schizophrenia. REFLEX focuses on targeting stigma-sensitivity, perspective taking and se...

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Bibliographic Details
Published in:Schizophrenia research 2019-04, Vol.206, p.362-369
Main Authors: Pijnenborg, G.H.M., de Vos, A.E., Timmerman, M.E., Van der Gaag, M., Sportel, B.E., Arends, J., Koopmans, E.M., Van der Meer, L., Aleman, A.
Format: Article
Language:English
Subjects:
Awareness
Clinical trial
Perspective taking
Schizophrenia
Self-reflection
Self-stigma
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Summary:The majority of people with schizophrenia has impaired insight, which is related to a poorer outcome. In this study, we evaluate a new psychosocial intervention ‘REFLEX’ aimed at improving insight in people with schizophrenia. REFLEX focuses on targeting stigma-sensitivity, perspective taking and self-reflection in people with schizophrenia and low insight. Primary objective is to improve insight and subsequently to improve functional outcome and symptoms. A total of 121 people diagnosed with schizophrenia according to DSM IV criteria with impaired insight was included in 2012–2015 from seven sites in a multicenter randomized controlled trial. REFLEX was compared to an active control condition consisting of group-wise simplified cognitive remediation training. Primary outcome of the study were the preconditions of insight: internalized stigma, self-reflection, mental flexibility and perspective taking. Clinical insight and cognitive insight were secondary outcomes. Although perspective taking, self-reflection, mental flexibility and stigma sensitivity remained unchanged after the intervention, results showed a significant improvement of clinical insight in both conditions directly after treatment (SAI-E Rater, p 
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2018.10.018