Biological evaluation of some quinoline derivatives with different functional groups as anticancer agents

Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N‐oxide, and methoxy) quinoline derivatives (3‐13) were te...

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Bibliographic Details
Published in:Journal of biochemical and molecular toxicology 2019-03, Vol.33 (3), p.e22260-n/a
Main Authors: Köprülü, Tuğba Kul, Ökten, Salih, Tekin, Şaban, Çakmak, Osman
Format: Article
Language:English
Subjects:
5-Fluorouracil
Adenocarcinoma
Animals
Anticancer properties
Antineoplastic Agents - pharmacology
Antitumor agents
Apoptosis
Apoptosis - drug effects
Biological activity
Cancer
cancer cells
Cell death
Cell Line, Tumor
Cell Proliferation - drug effects
Cervical cancer
Cervix
cytotoxic activity
Cytotoxicity
Derivatives
Drug development
Drug Screening Assays, Antitumor
Functional groups
Glioblastoma
HeLa Cells
Humans
Nitro Compounds - pharmacology
nitroquinoline
phenylquinoline
Quinoline
quinolines
Quinolines - pharmacology
Rats
Tumor cell lines
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Summary:Due to a great deal of biological activities, quinoline derivatives have drawn attention for synthesis and biological activities in the search for new anticancer drug development. In this work, a variety of substituted (phenyl, nitro, cyano, N‐oxide, and methoxy) quinoline derivatives (3‐13) were tested in vitro for their biological activity against cancer cell lines, including rat glioblastoma (C6), human cervical cancer cells (HeLa), and human adenocarcinoma (HT29). 6‐Bromo‐5‐nitroquinoline (4), and 6,8‐diphenylquinoline (compound 13) showed the greatest antiproliferative activity as compared with the reference drug, 5‐fluorouracil (5‐FU), while the other compounds showed low antiproliferative activity. 6‐Bromo‐5‐nitroquinoline (4) possesses lower cytotoxic activity than 5‐FU in HT29 cell line. Due to its the apoptotic activity 6‐Bromo‐5‐nitroquinoline (4) has the potential to cause cancer cell death.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22260