Transforming growth factor b-1 as a predictor of fibrosis in tuberculous pleurisy

Background and objective: To clarify the influence of transforming growth factor b-1 (TGF-b sub(1)) in the development of pleural thickening in tuberculosis (TB), the levels of TGF-b sub(1) in pleural fluid and in serum of patients with pleural TB and transudative effusions were determined. Methods:...

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Published in:Respirology (Carlton, Vic.) Vic.), 2007-09, Vol.12 (5), p.660-663
Main Authors: SEISCENTO, Marcia, VARGAS, Francisco S, ANTONANGELO, Leila, ACENCIO, Milena MP, BOMBARDA, Sidney, CAPELOZZI, Vera L, TEIXEIRA, Lisete R
Format: Article
Language:English
Subjects:
Mycobacterium
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Summary:Background and objective: To clarify the influence of transforming growth factor b-1 (TGF-b sub(1)) in the development of pleural thickening in tuberculosis (TB), the levels of TGF-b sub(1) in pleural fluid and in serum of patients with pleural TB and transudative effusions were determined. Methods: TGF-b sub(1) was quantified in 58 pleural fluid and serum samples of patients with TB (n = 50) or transudative effusions (n = 8). Pleural thickening evaluated by high-resolution CT was scored as 0 (
ISSN:1323-7799
1440-1843
DOI:10.1111/j.1440-1843.2007.01135.x