Computational Simulation of Array-based Electroporation in the Cochlea

We present a computational model for predicting electric field distributions following array-based closed-loop electroporation in the cochlea. The model geometry was reconstructed from magnetic resonance images of the guinea pig cochlea and an eight-channel electrode array embedded within this geome...

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Bibliographic Details
Main Authors: Al Abed, Amr, Foster, Evelyn, Pinyon, Jeremy L., Chung Hon Li, Cowin, Gary J., Housley, Gary D., Lovell, Nigel H.
Format: Conference Proceeding
Language:English
Subjects:
Cathodes
Computational modeling
Electric fields
Electric potential
Geometry
Predictive models
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Summary:We present a computational model for predicting electric field distributions following array-based closed-loop electroporation in the cochlea. The model geometry was reconstructed from magnetic resonance images of the guinea pig cochlea and an eight-channel electrode array embedded within this geometry. The model's electrode voltage output waveform was obtained from electric potential mapping conducted in physiological solution following constant-current stimulation using the electrode array. Our simulations predict that a tandem electrode configuration with four ganged cathodes and four ganged anodes produces a larger area in target tissue where the electric field is within the range for successful gene transfer compared to an alternate paired anode-cathode electrode configuration. These findings corroborate published in vivo evidence comparing the two configurations and support the utility of the developed model as a tool to optimize the efficacy of electroporation electrodes.
ISSN:1558-4615
2694-0604
DOI:10.1109/EMBC.2018.8512808