Laser speckle contrast imaging of blood flow in the deep brain using microendoscopy

Poor blood flow circulation can occur in the subcortical regions of the brain in many brain diseases. However, the limitations of light penetration imaging techniques hinder the detection of blood flow in deep brain tissues in vivo. Hence, in this Letter, we present a gradient index lens-based laser...

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Bibliographic Details
Published in:Optics letters 2018-11, Vol.43 (22), p.5627-5630
Main Authors: Chen, Ming, Wen, Dong, Huang, Songlin, Gui, Shen, Zhang, Zhihong, Lu, Jinling, Li, Pengcheng
Format: Article
Language:English
Subjects:
Animals
Blood circulation
Blood flow
Brain
Cerebrovascular Circulation
Endoscopy - methods
Hemodynamics
Hypoxia
Imaging techniques
Lasers
Male
Medical imaging
Mice
Mice, Inbred C57BL
Molecular Imaging - methods
Occlusion
Thalamus
Thalamus - blood supply
Thalamus - diagnostic imaging
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Summary:Poor blood flow circulation can occur in the subcortical regions of the brain in many brain diseases. However, the limitations of light penetration imaging techniques hinder the detection of blood flow in deep brain tissues in vivo. Hence, in this Letter, we present a gradient index lens-based laser speckle contrast imaging system for time-lapse blood flow detection in subcortical regions of the brain. We monitored the hemodynamic changes in the thalamus of mouse models of acute hypoxia and transient middle cerebral artery occlusion as a proof of concept for practical applications.
ISSN:0146-9592
1539-4794
DOI:10.1364/ol.43.005627