Is perivitelline space morphology of the oocyte associated with pregnancy outcome in intracytoplasmic sperm injection cycles?

To investigate the effect of perivitelline space (PVS) abnormalities on the outcomes of intracytoplasmic sperm injection (ICSI) cycles in which the entire cohort was affected. Data from 9752 oocytes obtained from 1151 ICSI cycles performed from June/2010 to August/2016 in a private university-affili...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2018-12, Vol.231, p.225-229
Main Authors: Ferrarini Zanetti, Bianca, Paes de Almeida Ferreira Braga, Daniela, Souza Setti, Amanda, de Cássia Sávio Figueira, Rita, Iaconelli Jr, Assumpto, Borges Jr, Edson
Format: Article
Language:English
Subjects:
Adult
Female
Humans
ICSI
Large perivitelline space
Oocyte dysmorphism
Oocyte morphology
Oocytes - pathology
Perivitelline space granularity
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Sperm Injections, Intracytoplasmic
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Summary:To investigate the effect of perivitelline space (PVS) abnormalities on the outcomes of intracytoplasmic sperm injection (ICSI) cycles in which the entire cohort was affected. Data from 9752 oocytes obtained from 1151 ICSI cycles performed from June/2010 to August/2016 in a private university-affiliated IVF centre. Cycles were divided into four groups according to the presence or absence of PVS abnormalities: PVS-L group (cycles with the entire oocyte cohort affected by large PVS, n = 265), PVS-G group (cycles with the entire oocyte cohort affected by PVS granularity, n = 280), PVS-L + PVS-G group (cycles with the entire oocyte cohort affected by PVS-L and PVS-G, n = 204), and control group (cycles with the entire oocyte cohort free of PVS abnormalities, n = 402). The effect of PVS abnormalities on ICSI outcomes was assessed by GLM adjusted for potential confounders. Groups with PVS abnormalities presented substantially higher FSH/follicle (p 
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2018.10.053